Human C-Peptide Alexa Fluor® 405-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: C-Peptide

Insulin is a peptide hormone that facilitates the cellular uptake of glucose by regulating the appearance of membrane glucose transporters. The single chain insulin propeptide consists of a 30 amino acid B chain (aa 25-54), a C-Peptide (aa 55-89), and a 21 aa A chain (aa 90-110). Removal of the C-Peptide by proteolysis enables the formation of mature Insulin, a disulfide-linked heterodimer of the A and B chains. Circulating C-peptide levels are elevated in hyperinsulinism, obesity, and type II diabetes. The human C-Peptide shares 61% and 68% aa sequence identity with mouse and rat C-Peptide, respectively.

Product Datasheets

Related Research Areas

• Diabetes
• Endocrine Regulation of Lipid Metabolism
• Glucose Homeostasis
• Growth Hormone/IGF-I Axis
• IGF Family
• Metabolic Peptide Hormones and Regulators
• Metabolism
• Nutrition and Appetite
• Pancreatic Endoderm
• Pancreatic Endoderm Cell Markers
• Preeclampsia