Human Calsyntenin-1 Antibody Summary
Accession # AAH33902
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Detection of Human Calsyntenin‑1 by Western Blot. Western blot shows lysates of human brain cortex and brain cerebellum tissue. PVDF membrane was probed with 1 µg/mL of Sheep Anti-Human Calsyntenin‑1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5346) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016). A specific band was detected for Calsyntenin‑1 at approximately 115 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Calsyntenin-1 (CST-1; also Alcadein-alpha ) is a 140‑150 kDa member of the Alcadein family of molecules. It is expressed in the ER/Golgi and on the plasma membranes of almost all neurons. It is a calcium-binding protein that may regulate post-synaptic signaling and APP cleavage and gene activation. Notably, when cleaved in a manner similar to APP, its intracellular fragment antagonizes APP AICD gene activation. Mature human CST-1 is a 953 amino acid (aa) type I transmembrane protein. It contains two cadherin domains (aa 38‑265) in its extracellular region (aa 29‑859) and a 101 aa cytoplasmic tail. Extracellular cleavage occurs at Met825 Ala826, generating a soluble 115 kDa ECD. Isoforms involve a 78 aa substitution for aa 917‑981, plus deletions of aa 72‑81 and 507‑525. Over aa 30‑851, human CST-1 shares 92% aa identity with mouse CST-1.
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