Human CD36/SR-B3 Antibody
Human CD36/SR-B3 Antibody Summary
Accession # P16671
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
CD36, alternatively known as platelet membrane glycoprotein IV (GPIV), GPIIIb, thrombospondin receptor, collagen receptor, fatty acid translocase (FAT), and scavenger receptor class B, member 3 (SR-B3), is an integral membrane glycoprotein that has multiple physiological functions (1). It is broadly expressed on a variety of cell types including microvascular endothelium, adipocytes, skeletal muscle, epithelial cells of the retina, breast, and intestine, smooth muscle cells, erythroid precursors, platelets, megakaryocytes, dendritic cells, monocytes/macrophages, and microglia (1, 2). As a member of the scavenger receptor family, CD36 is a multiligand pattern recognition receptor that interacts with a large number of structurally dissimilar ligands, including long chain fatty acid (LCFA), advanced glycation end products (AGE), thrombospondin-1, oxidized low-density lipoproteins (oxLDLs), high density lipoprotein (HDL), phosphatidylserine, apoptotic cells, beta -amyloid fibrils (fA beta ), collagens I and IV, and Plasmodium falciparum-infected erythrocytes (3). CD36 is required for the anti-angiogenic effects of thrombospondin-1 in the corneal neovascularization assay (4). It plays a role in lipid metabolism and has been identified as a fatty acid translocase necessary for the binding and transport of LCFA in cells and tissues (5). CD36 has been implicated in the clearance of apoptotic cells and cell debris and has also been shown to mediate the internalization and degradation of a variety of its ligands such as oxLDL, AGE and fA beta (3). Upon ligand binding, CD36 transduces signals that mediate a wide range of pro-inflammatory cellular responses (2). CD36 plays a significant role in the initiation and pathogenesis of chronic inflammatory diseases such as Alzheimer’s disease and atherosclerosis (2, 3). The human CD36 gene encodes a single-chain 472 amino acid residue protein containing both an N- and a C-terminal cytoplasmic tail and an extracellular loop.
- Febbraio, M. et al. (2001) J. Clin. Invest. 108:785.
- Khoury, J. et al. (2003) J. Exp. Med. 197:1657.
- Husemann, J. et al. (2002) Glia 40:195.
- Armstrong, L and P. Bornstein (2003) Matrix. Biol. 22:63.
- Febbraio M. et al. (1999) J. Biol. Chem. 274:19055.
Citations for Human CD36/SR-B3 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
Citations: Showing 1 - 3
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Adipocyte-induced transdifferentiation of osteoblasts and its potential role in age-related bone loss
Authors: A Clabaut, C Grare, G Rolland-Va, JG Letarouill, C Bourrier, TL Andersen, T Sikjær, L Rejnmark, C Ejersted, P Pastoureau, P Hardouin, M Sabatini, O Broux
PLoS ONE, 2021;16(1):e0245014.
Sample Types: Whole Tissue
Contribution of rare coding mutations in CD36 to type 2 diabetes and cardio-metabolic complications
Authors: D Meyre, EJ Andress, T Sharma, M Snippe, H Asif, A Maharaj, V Vatin, S Gaget, P Besnard, H Choquet, P Froguel, KJ Linton
Sci Rep, 2019;9(1):17123.
Sample Types: Cell Lysates
Applications: Western Blot
Red blood cell phosphatidylserine exposure is responsible for increased erythrocyte adhesion to endothelium in central retinal vein occlusion.
Authors: Wautier MP, Heron E, Picot J, Colin Y, Hermine O, Wautier JL
J. Thromb. Haemost., 2011;9(5):1049-55.
Sample Types: Whole Cells
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