Human CD37 Fluorescein-conjugated Antibody

    
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  • Species Reactivity
    Human
  • Specificity
    Detects human CD37. Stains human CD37 transfectants but not irrelevant transfectants.
  • Source
    Monoclonal Mouse IgG2A Clone # 424925
  • Purification
    Protein A or G purified from hybridoma culture supernatant
  • Immunogen
    Mouse myeloma cell line NS0-derived recombinant human CD37 Accession # NP_001765
  • Formulation
    Supplied in a saline solution containing BSA and Sodium Azide.
  • Label
    Fluorescein
Product Datasheets

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Applications
  •  
    Recommended
    Concentration
    Sample
  • Flow Cytometry
    10 µL/106 cells
    See below
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Data Example
Detection of CD37 in Human Monocytes by Flow Cytometry. Human monocytes were stained with Mouse Anti-Human CD37 Fluorescein‑conjugated Monoclonal Antibody (Catalog # FAB4625F, filled histogram) or isotype control antibody (Catalog # IC003F, open histogram). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
  • Shipping
    The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
  • Stability & Storage
    Protect from light. Do not freeze.
      12 months from date of receipt, 2 to 8 degreesC as supplied.
Background: CD37
CD37, also known as TSPAN26, is a 40-60 kDa palmitoylated tetraspanin superfamily glycoprotein that is expressed principally by B cells, but also by T cells, NK cells and APCs. CD37 directly associates with multiple partners, incuding Dectin-1 on APCs, Integrin alpha 4 beta 1 on plasma cells, MHC-II molecules on dendritic cells, and additional tetraspanins such as CD53, CD81, and CD82 on various cell types. It appears to play a role in immune downmodulation, as its association with Dectin-1 reduces APC cytokine release, and its association with MHC-II depresses T-cell stimulation. Consistent with membership in the tetraspanin family, CD37 has cytoplasmic N- and C-termini. Notably perhaps, signaling through the N-terminus initiates cell death while signaling through the C-terminus promotes cell survival. Over amino acids constituting the CD37 extracellular domain, human and mouse share 69% amino acid sequence identity.
  • Entrez Gene IDs:
    951 (Human); 12493 (Mouse); 29185 (Rat)
  • Alternate Names:
    CD37 antigentetraspanin-26; CD37 molecule; CD37; cell differentiation antigen 37; GP52-40; leukocyte antigen CD37; MGC120234; Tetraspanin-26; TSPAN26; tspan-26; TSPAN26leukocyte surface antigen CD37
Related Research Areas

FAQs

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Isotype Controls
Description Application Cat# Citations Images  

Mouse IgG2A Fluorescein-conjugated Antibody

Ctrl IC003F 6  
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Staining Reagents
Description Application Cat# Citations Images  

Flow Cytometry Staining Buffer (1X)

Flow FC001 10
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Flow Cytometry Mouse Lyse Buffer (10X)

Flow FC003 5
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Flow Cytometry Human Lyse Buffer (10X)

Flow FC002 1
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