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Human CD46 PE-conjugated Antibody

Catalog #: FAB2005P
1 Citation Datasheet / COA / SDS

Discontinued Product

FAB2005P has been discontinued.
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Detection of CD46 in Human Blood Lymphocytes by Flow Cytometry.
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Citations (1)
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Human CD46 PE-conjugated Antibody Summary

Species Reactivity
Human
Specificity
Detects human CD46 in direct ELISAs and Western blots.
Source
Monoclonal Mouse IgG2B Clone # 344519
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Mouse myeloma cell line NS0-derived recombinant human CD46
Cys35-Asp328
Accession # NP_722548
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Label
Phycoerythrin (Excitation= 488 nm, Emission= 565-605 nm)

Applications

Recommended Concentration
Sample
Flow Cytometry
10 µL/106 cells
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry Detection of CD46 antibody in Human Blood Lymphocytes antibody by Flow Cytometry. View Larger

Detection of CD46 in Human Blood Lymphocytes by Flow Cytometry. Human whole blood lymphocytes were stained with Mouse Anti-Human CD46 PE-conjugated Monoclonal Antibody (Catalog # FAB2005P, filled histogram) or isotype control antibody (Catalog # IC0041P, open histogram). View our protocol for Staining Membrane-associated Proteins.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at 2 - 8° C. Do not use past expiration date. Protect from light.

Background: CD46

CD46, also known as MCP, is a type I membrane protein that functions as a cofactor for Complement Factor I-mediated inactivation of complement components C3b and C4b. CD46 is expressed in white blood cells, platelets, epithelial cells, and fibroblasts. The extracellular region of CD46 contains four tandem Sushi domains. At least fourteen transcript variants encode isoforms with deletions or substitutions following the fourth Sushi domain. Within corresponding regions, human CD46 shares 50% amino acid sequence identity with mouse and rat CD46.

Entrez Gene IDs
4179 (Human); 17221 (Mouse)
Alternate Names
AHUS2; CD46 antigen; CD46 molecule, complement regulatory protein; CD46; MCP; membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen); MIC10; TLXcomplement regulatory protein; trophoblast leucocyte common antigen; Trophoblast leukocyte common antigen; trophoblast-lymphocyte cross-reactive antigen

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Citation for Human CD46 PE-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

  1. Mev-stealth: A cd46-specific oncolytic measles virus resistant to neutralization by measles-immune human serum
    Authors: MÁ Muñoz-Alía, RA Nace, A Tischer, L Zhang, ES Bah, M Auton, SJ Russell
    PloS Pathogens, 2021-02-03;17(2):e1009283.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry

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