Human CELSR3 PE‑conjugated Antibody

R&D Systems | Catalog # FAB7278P

R&D Systems
Discontinued Product
FAB7278P has been discontinued. View all CELSR3 products.

Key Product Details

Species Reactivity

Human

Applications

Flow Cytometry

Label

Phycoerythrin (Excitation = 488 nm, Emission = 565-605 nm)

Antibody Source

Monoclonal Mouse IgG2B Clone # 763103
View all CELSR3 Primary Antibodies »

Product Specifications

Immunogen

E. coli-derived recombinant human CELSR3
Val531-Ser711
Accession # Q9NYQ7

Specificity

Detects human CELSR3 in ELISA.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Scientific Data Images for Human CELSR3 PE‑conjugated Antibody

Detection of CELSR3 antibody in SH‑SY5Y Human Cell Line antibody by Flow Cytometry.

Detection of CELSR3 in SH‑SY5Y Human Cell Line by Flow Cytometry.

SH-SY5Y human neuroblastoma cell line was stained with Mouse Anti-Human CELSR3 PE-conjugated Monoclonal Antibody (Catalog # FAB7278P, filled histogram) or isotype control antibody (Catalog # IC0041P, open histogram). View our protocol for Staining Membrane-associated Proteins.

Applications for Human CELSR3 PE‑conjugated Antibody

Application
Recommended Usage

Flow Cytometry

10 µL/106 cells
Sample: SH‑SY5Y human neuroblastoma cell line

Spectra Viewer

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Flow Cytometry

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

Supplied in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: CELSR3

CELSR3 (Cadherin EGF LAG Seven-pass G-type Receptor 3; also cadherin family member 11/CDHF11, FMI1 and EGFL1) is a 355 kDa (predicted) member of the LN-7TM subfamily, GPCR 2 family of proteins. It is coexpressed with Fzd3 on postmigratory neurons of the developing DRG and cranial ganglia, and appears to serve as an axonal guidance cue. Mature human CELSR3 is 3280 amino acids (aa) in length (aa 33-3312). It is a highly complex 7-transmembrane protein that contains a 2508 aa extended N-terminal extracellular region (aa 33-2540) plus a 538 aa C-terminal cytoplasmic domain. The N-terminal region contains nine consecutive cadherin domains (aa 326-1265), followed by a mixture of eight EGF-like and three laminin-like domains, and one membrane-proximal GPS domain. There are two potential isoform variants. One shows a five aa insertion after Gly2158, while another possesses an alternative start site at Met276. Over aa 531-711, human CELSR3 shares 98% aa sequence identity with mouse CELSR3.

Long Name

Cadherin, EGF LAG Seven-pass G-type Receptor 3

Alternate Names

CDHF11, EGFL1, HFMI1, MEGF2, RESDA1

Entrez Gene IDs

1951 (Human); 107934 (Mouse); 83466 (Rat)

Gene Symbol

CELSR3

UniProt

Q9NYQ7 (Human)

Additional CELSR3 Products

Product Documents for Human CELSR3 PE‑conjugated Antibody

Certificate of Analysis

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Product Specific Notices for Human CELSR3 PE‑conjugated Antibody

For research use only

Related Research Areas

Cadherin Superfamily
Wnt Receptors

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