|Detection of Dopamine D1 R/DRD1 in HEK293 Human Cell Line Transfected with Human Dopamine D1 R/DRD1 and eGFP by Flow Cytometry. HEK293 human embryonic kidney cell line transfected with (A) human Dopamine D1 R/DRD1 or (B) irrelevant transfectants and eGFP was stained with Mouse Anti-Human Dopamine D1 R/DRD1 PE‑conjugated Monoclonal Antibody (Catalog # FAB8276P) and. Quadrant markers were set based on control antibody staining (Catalog # IC003P). View our protocol for Staining Membrane-associated Proteins.|
Dopamine Receptor D1 (DRD1) is a 50 kDa member of class 1 GPCR superfamily and is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. DRD1 is associated with nicotine dependence, schizophrenia, and systolic blood pressure levels.