Human ER beta/NR3A2 Antibody

Catalog # Availability Size / Price Qty
PP-PPZ0506-00
Product Details
Citations (6)
FAQs
Supplemental Products
Reviews (1)

Human ER beta/NR3A2 Antibody Summary

Species Reactivity
Human
Source
Monoclonal Mouse IgG2b Clone # PPZ0506
Formulation
A liquid formulation in physiologic saline with 0.1% NaN3.

Applications

Recommended Concentration
Sample
Western Blot
Please refer to the PDF datasheet for specifications.
Immunoprecipitation
Please refer to the PDF datasheet for specifications.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: ER beta/NR3A2

Estrogen Receptor beta (ERβ,NR3A2) is a member of the steroid receptor family. The natural ligand for ER is the classical estrogenic compound 17β-estradiol. ERβ is expressed in the granulosa cell layer of primary, secondary and mature follicles in the ovary, in bone, bladder, uterus, testis, epididymis, gastrointestinal tract, kidney, breast, heart, vessel wall, immune system, lung, pituitary, hippocampus and hypothalamus. Roles for ERβ in the reproductive and cardiovascular systems have been reported, although these are the subject of conflicting reports. ERβ has been postulated to act primarily as a modulator of ERα function. ER&beta has been shown to form homodimers as well as heterodimers with ERα. Both ERα and ERβ can give rise to numerous isoforms.

Long Name
Estrogen Receptor beta
Entrez Gene IDs
2100 (Human)
Alternate Names
ER beta; Erb; ER-beta; ESR2; ESR-BETA; ESTRB; estrogen receptor 2 (ER beta); estrogen receptor beta 4; estrogen receptor beta; NR3A2; NR3A2ESRB; Nuclear receptor subfamily 3 group A member 2

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Citations for Human ER beta/NR3A2 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

6 Citations: Showing 1 - 6
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  1. Ovarian ER? cistrome and transcriptome reveal chromatin interaction with LRH-1
    Authors: Birgersson, M;Indukuri, R;Lindquist, L;Stepanauskaite, L;Luo, Q;Deng, Q;Archer, A;Williams, C;
    BMC biology
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  2. Immunohistochemical Detection of Estrogen Receptor-Beta (ERbeta) with PPZ0506 Antibody in Murine Tissue: From Pitfalls to Optimization
    Authors: SK Schröder, CG Tag, JC Kessel, P Antonson, R Weiskirche
    Biomedicines, 2022-12-01;10(12):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  3. ER alpha and ER beta Homodimers in the Same Cellular Context Regulate Distinct Transcriptomes and Functions
    Authors: Dandan Song, Huan He, Rajitha Indukuri, Zhiqiang Huang, Lina Stepanauskaite, Indranil Sinha et al.
    Front Endocrinol (Lausanne)
  4. Estrogen Receptor beta (ESR2) Transcriptome and Chromatin Binding in a Mantle Cell Lymphoma Tumor Model Reveal the Tumor-Suppressing Mechanisms of Estrogens
    Authors: Dan Huang, Zhiqiang Huang, Rajitha Indukuri, Chandrashekar Bangalore Revanna, Mattias Berglund, Jiyu Guan et al.
    Cancers (Basel)
  5. A Presurgical‐Window Intervention Trial of Isothiocyanate‐Rich Broccoli Sprout Extract in Patients with Breast Cancer
    Authors: Zinian Wang, Chengjian Tu, Rachel Pratt, Thaer Khoury, Jun Qu, Jed W. Fahey et al.
    Molecular Nutrition & Food Research
  6. Expression of oestrogen receptors (GPER, ESR1, ESR2) in human ductuli efferentes and proximal epididymis
    Authors: Rago V, Romeo F, Giordano F et al.
    Andrology
    Species: Human
    Sample Types:
    Applications: IHC

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Reviews for Human ER beta/NR3A2 Antibody

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Human ER beta/NR3A2 Antibody
By Cecilia Williams on 08/15/2017
Application: IHC Sample Tested: Cancer Tissue,Normal tissue Species: Human

The present antibody proved excellent for IHC (1:600 dilution) of formalin-fixed paraffin-embedded tissues and cells, Western blotting (1:1000) and IP as determined by comparing results from ERbeta-positive cells and ERbeta-negative cells, and corroborated by mass spectrometry. It was tested on a wide range of human normal tissues and cancer, and correlated to mRNA levels (RNA-seq). It stained the nucleus of granulosa cells of the normal ovary, testis, adrenal gland, tonsil, and lymphocytes in various tissues; tumor cells of granulosa cell tumors and a subset of malignant melanoma.
See full article at Nature Communications (Andersson et al, 2017): https://www.nature.com/articles/ncomms15840