Human ER beta/NR3A2 Antibody
Human ER beta/NR3A2 Antibody Summary
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Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
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Background: ER beta/NR3A2
Estrogen Receptor beta (ERβ,NR3A2) is a member of the steroid receptor family. The natural ligand for ER is the classical estrogenic compound 17β-estradiol. ERβ is expressed in the granulosa cell layer of primary, secondary and mature follicles in the ovary, in bone, bladder, uterus, testis, epididymis, gastrointestinal tract, kidney, breast, heart, vessel wall, immune system, lung, pituitary, hippocampus and hypothalamus. Roles for ERβ in the reproductive and cardiovascular systems have been reported, although these are the subject of conflicting reports. ERβ has been postulated to act primarily as a modulator of ERα function. ER&beta has been shown to form homodimers as well as heterodimers with ERα. Both ERα and ERβ can give rise to numerous isoforms.
Product Datasheets
Citation for Human ER beta/NR3A2 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
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Immunohistochemical Detection of Estrogen Receptor-Beta (ERbeta) with PPZ0506 Antibody in Murine Tissue: From Pitfalls to Optimization
Authors: SK Schröder, CG Tag, JC Kessel, P Antonson, R Weiskirche
Biomedicines, 2022;10(12):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC
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The present antibody proved excellent for IHC (1:600 dilution) of formalin-fixed paraffin-embedded tissues and cells, Western blotting (1:1000) and IP as determined by comparing results from ERbeta-positive cells and ERbeta-negative cells, and corroborated by mass spectrometry. It was tested on a wide range of human normal tissues and cancer, and correlated to mRNA levels (RNA-seq). It stained the nucleus of granulosa cells of the normal ovary, testis, adrenal gland, tonsil, and lymphocytes in various tissues; tumor cells of granulosa cell tumors and a subset of malignant melanoma.
See full article at Nature Communications (Andersson et al, 2017): https://www.nature.com/articles/ncomms15840
