Human ErbB2/Her2 (Research Grade Trastuzumab Biosimilar) Antibody
Human ErbB2/Her2 (Research Grade Trastuzumab Biosimilar) Antibody Summary
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Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of ErbB2/Her2 in MCF-7 human cell line by Flow Cytometry. MCF-7 human cell line was stained with Human Anti-Human ErbB2/Her2 (Research Grade Trastuzumab Biosimilar) Monoclonal Antibody (Catalog # MAB9589, filled histogram) or Human IgG Control Antibody (1-001-A, open histogram) followed by APC-conjugated Anti-Human IgG Secondary Antibody (Catalog # F0135). View our protocol for Staining Membrane-associated Proteins.
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Detection of ErbB2/Her2 in MDA-MB-453 human cell line by Flow Cytometry. MDA-MB-453 human cell line was stained with Human Anti-Human ErbB2/Her2 (Research Grade Trastuzumab Biosimilar) Monoclonal Antibody (Catalog # MAB9589, filled histogram) or Human IgG Control Antibody (1-001-A, open histogram) followed by APC-conjugated Anti-Human IgG Secondary Antibody (Catalog # F0135). View our protocol for Staining Membrane-associated Proteins.
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Inhibition of Cell Proliferation by ErbB2/Her2 (Research Grade Trastuzumab Biosimilar) Antibody. Human Anti-Human ErbB2/Her2 (Research Grade Trastuzumab Biosimilar) Monoclonal Antibody (Catalog # MAB9589) inhibits proliferation in the SK-BR-3 human breast cancer cell line as measured by Resazurin (Catalog # AR002). The ED50 for this effect is typically 15-75 ng/mL.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: ErbB2/Her2
Trastuzumab is a biosimilar directed against the extracellular domain of Her2 (ErbB2). This product constitutes the immunogen used for the anti-Idiotype catalog numbers MAB9547 and MAB95471. The biotinylated antibody (catalog number FAB9589B) can be used in flow cytometry or various assay formats to measure Her2 expression and can be detected by conjugated streptavidin.
Product Datasheets
Citations for Human ErbB2/Her2 (Research Grade Trastuzumab Biosimilar) Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 2
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Erb-b2 Receptor Tyrosine Kinase 2 (ERBB2) Promotes ATG12-Dependent Autophagy Contributing to Treatment Resistance of Breast Cancer Cells
Authors: Y Chen, R Wang, S Huang, ES Henson, J Bi, SB Gibson
Cancers, 2021;13(5):.
Species: Human
Sample Types: Cell Lysates
Applications: Immunoprecipitation -
Population-wide diversity and stability of serum antibody epitope repertoires against human microbiota
Authors: T Vogl, S Klompus, S Leviatan, IN Kalka, A Weinberger, C Wijmenga, J Fu, A Zhernakova, RK Weersma, E Segal
Nature Medicine, 2021;0(0):.
Species: Staphylococcus
Sample Types:
Applications: Neutralization Control
FAQs
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What is a Biosimilar antibody?
A Biosimilar antibody is a non-therpeutic, recombinantly-expressed antibody which has the same sequence as the corresponding therapeutic antibody. It is for research use only. The nomenclature of the Biosimilar antibody includes the name of the therapeutic antibody. For example, Catalog # MAB9577 is called Human EGFR (Research Grade CetuxiMab Biosimilar) antibody.
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Does this Biosimilar antibody have the same sequence as its corresponding therapeutic antibody?
This Biosimilar antibody has the same variable region sequence as the therapeutic antibody, but the constant region is not the same. It contains a proprietary human IgG constant region.
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Is an isotype control available for human IgG Biosimilar Antibodies?
Unfortunately, we do not offer isotype controls for Biosimilar antibodies at this time. We do have a polyclonal Normal Human IgG Control, Catalog # 1-001-A.
Reconstitution Buffers
Reviews for Human ErbB2/Her2 (Research Grade Trastuzumab Biosimilar) Antibody
Average Rating: 3.5 (Based on 2 Reviews)
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