Human Erythropoietin R Biotinylated Antibody
Human Erythropoietin R Biotinylated Antibody Summary
Accession # P19235
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Erythropoietin R
Erythropoietin (Epo), a glycoprotein produced primarily by the kidney, is the principal factor that regulates erythropoiesis by stimulating the proliferation and differentiation of erythroid progenitor cells. The biological effects of Epo are mediated by the erythropoietin receptor (Epo R). The genes for human and mouse Epo R have been cloned and characterized. The full-length human Epo R cDNA encodes a type I membrane-spanning protein with 508 amino acid (aa) residues (a 24 aa residue hydrophobic signal sequence, a 226 aa residue extracellular domain, a 22 aa residue transmembrane domain and a 236 aa residue cytoplasmic domain). At the protein sequence level, the human Epo R is approximately 82% identical to the mouse protein. As a result of alternative splicing of the Epo R gene, cDNA clones encoding a truncated form of the Epo R as well as the soluble form of Epo R has been found. The presence of a soluble form of the Epo R has also been detected on human sera. Recombinant soluble Epo R binds Epo with high affinity and is a potent Epo antagonist.
- Barber, D.L. and A.D. D’Andrea (1992) Seminars in Hematology 29:293.
- Youssoufian, H. et al. (1993) Blood 9:2223.
- Lodish, H.F. et al. (1995) Cold Spring Harbor Symposia on Quantitative Biology LX:93 - 104.
- Baynes, R.D. et al. (1993) Blood 82:2088.
Citations for Human Erythropoietin R Biotinylated Antibody
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Erythropoietin mimetic compound AGEM400(HES) binds to the same receptor as erythropoietin but displays a different spectrum of activities.
Authors: Kessler C, Greindl A, Breuer B, Haberl U, Rybka A, Emgenbroich M, Frank HG, Potgens AJ
Sample Types: Whole Cells
Applications: Flow Cytometry
Characterization of erythropoietin receptor and erythropoietin expression and function in human ovarian cancer cells.
Authors: Jeong JY, Feldman L, Solar P, Szenajch J, Sytkowski AJ
Int. J. Cancer, 2008;122(2):274-80.
Sample Types: Cell Lysates
Applications: Western Blot
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