Human FRA-1 Alexa Fluor® 405-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: FRA-1

FRA-1 (FOSL1) is a 271 amino acid member of the leucine zipper Fos family of transcription factors. Fos family members have been associated with cellular proliferation, differentiation and transformation. In accordance with these findings, overexpression of FRA-1 correlates with a malignant phenotype in breast cancer. In lung epithelia cells, FRA-1 promotes motility, invasion, and anchorage independent growth. FRA-1 knock out mice rescued for the FRA-1 placental defect are viable but show reduced bone formation that may be due to a defect in the osteoblast differentiation. Human FRA-1 and mouse FRA-1 are 94% identical between amino acids 146-247.

Product Datasheets

Related Research Areas

• Apoptosis Transcription Factors and Regulators
• Basic Leucine Zipper (bZIP) Transcription Factors
• Cancer Stem Cell Transcription Factors
• C-type Lectin Receptors
• IL-1 Family
• IL-17 Family
• NOD-like Receptors and the Inflammasome
• Toll-Like Receptors
• Transcription Factors in the Akt Pathway
• VEGF Family