This antibody specifically recognizes human FXR and cross-reacts with rat
and mouse FXR. Not yet tested in other species.
Monoclonal Mouse IgG2A Clone # A9033A
Protein A or G purified from hybridoma culture supernatant
Recombinant human FXR/NR1H4 aa 2-126
A liquid formulation in
physiologic saline with
This antibody can be used at 1 μg/mL with the appropriatesecondary reagents to detect human FXR.
This antibody can be used at 20-40 μg/mL with theappropriate secondary reagents to detect human FXR.
Optimal dilutions should be determined by eachlaboratory.
This antibody can be used at 0.2 μg/mL with the appropriatesecondary reagents to detect human FXR.
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
This antibody is stable for greater than six months when held at -20 °C in a
manual defrost freezer or at -70 °C. Upon thawing, the antibody can be
stored at 2-8 °C for at least 1 month without detectable loss of activity. Avoid
repeated freeze-thaw cycles.
Farnesoid X-activated Receptor (FXR, HRR-1, BAR, RIP14; NR1H4) is a
member of the Orphan Nuclear Receptor family. FXR is expressed in the liver,
intestinal villi, renal tubes and adrenal cortex. FXR is a global regulator of bile
acid metabolism. Two genes, cholesterol 7a-hydroxylase (CYP7A1) and
IBABP (Ileal Bile Acid Binding Protein), which are implicated in bile acid
biosynthesis and recycling, respectively, are target genes of FXR. FXR is
shown to be transcriptionally activated by farnesol metabolites such as
farnesol itself and juvenile hormone III. FXR binds to DNA only as a
heterodimer with Retinoid X Receptor (RXR).
Farnesoid X-activated receptor
Entrez Gene IDs:
9971 (Human); 20186 (Mouse); 60351 (Rat)
BAR; bile acid receptor; farnesoid X receptor; Farnesoid X-activated receptor; Farnesol receptor HRR-1; FXR; FXRBAR; HRR-1; HRR1MGC163445; NR1H4; Nuclear receptor subfamily 1 group H member 4; nuclear receptor subfamily 1, group H, member 4; Retinoid X receptor-interacting protein 14; RIP14; RIP14RXR-interacting protein 14
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