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Human IL-10 Biotinylated Fluorokine Flow Cytometry Kit

Catalog #: NF100
11 Citations Datasheet / COA / SDS

Discontinued Product

NF100 has been discontinued.
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Citations (11)
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Human IL-10 Biotinylated Fluorokine Flow Cytometry Kit Summary

Specifications

Source
N/A
Shipping Conditions
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Species
Human

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Background: IL-10

Interleukin-10 functions as an anti-inflammatory cytokine by inhibiting the expansion and activation of Th1 cells and Th17 cells and by promoting the development of M2 macrophages and regulatory T cells (Treg). Within a tumor microrenvironment, however, IL-10 can inhibit the expansion of both Treg and myeloid-derived suppressor cells (MDSC). IL-10 exerts protective effects including limiting tissue damage in arthritic inflammation and promoting muscle regeneration after injury, but it also contributes to the persistence of viral infections. IL-10 signals through a receptor complex composed of IL-10 R alpha and IL-10 R beta. IL-10 R beta additionally associates with IL-20 R alpha, IL-22 R alpha 1, or IL-28 R alpha to form the receptor complexes for IL-22, IL-26, IL-28, and IL-29.

Long Name
Interleukin 10
Entrez Gene IDs
3586 (Human); 16153 (Mouse); 25325 (Rat); 397106 (Porcine); 403628 (Canine); 102133450 (Cynomolgus Monkey); 100034187 (Equine); 493683 (Feline); 100715618 (Guinea Pig); 2949786 (Viral)
Alternate Names
CSIF; CSIFMGC126450; Cytokine synthesis inhibitory factor; GVHDS; IL10; IL-10; IL10A; IL-10MGC126451; interleukin 10; interleukin-10; TGIF

Citations for Human IL-10 Biotinylated Fluorokine Flow Cytometry Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

11 Citations: Showing 1 - 10
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  1. The role of ICOS in directing T cell responses: ICOS-dependent induction of T cell anergy by tolerogenic dendritic cells.
    Authors: Tuettenberg A, Huter E, Hubo M, Horn J, Knop J, Grimbacher B, Kroczek RA, Stoll S, Jonuleit H
    J. Immunol., 2009-03-15;182(6):3349-56.  2009-03-15
  2. Circulating and airway neutrophils in cystic fibrosis display different TLR expression and responsiveness to interleukin-10.
    Authors: Petit-Bertron AF, Tabary O, Corvol H, Jacquot J, Clement A, Cavaillon JM, Adib-Conquy M
    Cytokine, 2007-12-03;41(1):54-60.  2007-12-03
  3. IL-10 inhibits endothelium-dependent T cell costimulation by up-regulation of ILT3/4 in human vascular endothelial cells.
    Authors: Gleissner CA, Zastrow A, Klingenberg R, Kluger MS, Konstandin M, Celik S, Haemmerling S, Shankar V, Giese T, Katus HA, Dengler TJ
    Eur. J. Immunol., 2007-01-01;37(1):177-92.  2007-01-01
  4. Prostaglandin E2 augments IL-10 signaling and function.
    Authors: Cheon H, Rho YH, Choi SJ, Lee YH, Song GG, Sohn J, Won NH, Ji JD
    J. Immunol., 2006-07-15;177(2):1092-100.  2006-07-15
  5. Selective regulation of IL-10 signaling and function by zymosan.
    Authors: Du Z, Kelly E, Mecklenbrauker I, Agle L, Herrero C, Paik P, Ivashkiv LB
    J. Immunol., 2006-04-15;176(8):4785-92.  2006-04-15
  6. Inhibition of IL-10 receptor function in alveolar macrophages by Toll-like receptor agonists.
    Authors: Fernandez S, Jose P, Avdiushko MG, Kaplan AM, Cohen DA
    J. Immunol., 2004-02-15;172(4):2613-20.  2004-02-15
  7. Reprogramming of IL-10 activity and signaling by IFN-gamma.
    Authors: Herrero C, Hu X, Li WP, Samuels S, Sharif MN, Kotenko S, Ivashkiv LB
    J. Immunol., 2003-11-15;171(10):5034-41.  2003-11-15
  8. Adherence influences monocyte responsiveness to interleukin-10.
    Authors: Petit-Bertron AF, Fitting C, Cavaillon JM, Adib-Conquy M
    J. Leukoc. Biol., 2003-01-01;73(1):145-54.  2003-01-01
  9. Expression of interleukin-10 and its receptor is up-regulated in early pregnant versus cycling human endometrium.
    Authors: Vigano P, Somigliana E, Mangioni S, Vignali M, Di Blasio AM
    J. Clin. Endocrinol. Metab., 2002-12-01;87(12):5730-6.  2002-12-01
  10. Expression of the IL-10 receptor on human monocytes is moderately suppressed by glucocorticoids.
    Authors: Visser J, Nagelkerken L
    Int. Immunopharmacol., 2002-09-01;2(10):1491-3.  2002-09-01
  11. Regulatory activity of autocrine IL-10 on dendritic cell functions.
    Authors: Corinti S, la Sala A, Pastore S
    J. Immunol., 2001-04-01;166(7):4312-8.  2001-04-01

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