Detection of Integrin alpha 1/CD49a in HeLa Human Cell Line by Flow Cytometry.
HeLa human cervical epithelial carcinoma cell line was stained with Rabbit Anti-Human Integrin alpha 1/CD49a PE‑conjugated Monoclonal Antibody (Catalog # FAB8624P, filled histogram) or isotype control antibody (Catalog # IC105P, open histogram). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
12 months from date of receipt, 2 to 8 °C as supplied.
Background: Integrin alpha 1/CD49a
alpha 1 (also VLA-1, CD49a and Laminin and Collagen Receptor) is a
190‑210 kDa member of the integrin alpha chain family of molecules. It
is found on smooth muscle cells, osteoblasts, adipocytes and intestinal
epithelium. Integrin alpha 1 forms a noncovalent heterodimer with Integrin
beta 1, and serves as a divalent-cation dependent receptor for collagen
types I, IV, VI, XIII and XVI. It also binds the diarrhea-associated
NSP4 enterotoxin of rotavirus. Mature human Integrin alpha 1 is a 1151 amino
acid (aa) type I transmembrane glycoprotein that contains a 1113 aa
extracellular domain (ECD) and a 15 aa cytoplasmic tail. The ECD
contains one vWFA/I‑domain (aa 147‑360) that binds collagen, plus
multiple divalent cation binding sites. Potential splice variants exist
that show a two and four aa substitution for aa 765‑1179. Over
aa 29‑1141 (the ECD), human Integrin alpha 1 shares 88% aa identity with
mouse Integrin alpha 1.
Entrez Gene IDs:
3672 (Human); 109700 (Mouse); 25118 (Rat)
CD49 antigen-like family member A; CD49a antigen; CD49a; Integrin alpha 1; integrin, alpha 1; ITGA1; Laminin and collagen receptor; very late activation protein 1; VLA-1; VLA1integrin alpha-1
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