Human Integrin  alpha 4 beta 7/LPAM-1 (Research Grade Vedolizumab Biosimilar) PE-conjugated Antibody

Catalog #: FAB10078P Datasheet / COA / SDS
Recombinant Monoclonal Antibody For Research Use Only
Catalog # Availability Size / Price Qty
FAB10078P-100
Detection of Integrin alpha 4 beta 7/LPAM-1 in Human PBMC by Flow Cytometry.
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Human Integrin  alpha 4 beta 7/LPAM-1 (Research Grade Vedolizumab Biosimilar) PE-conjugated Antibody Summary

Species Reactivity
Human
Specificity
Detects human Integrin alpha 4 beta 7/LPAM‑1 in direct ELISAs. This non-therapeutic antibody uses the same variable region sequence as the therapeutic antibody Vedolizumab. This product is for research use only.
Source
Recombinant Monoclonal Human IgG1 Clone # Hu117
Purification
Protein A or G purified from cell culture supernatant
Immunogen
Human Integrin alpha 4 beta 7/LPAM‑1
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Label
Phycoerythrin (Excitation= 488 nm, Emission= 565-605 nm)

Applications

Recommended Concentration
Sample
Flow Cytometry
10 µL/106 cells
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry Detection of Integrin alpha 4 beta 7/LPAM-1 antibody in Human PBMC antibody by Flow Cytometry. View Larger

Detection of Integrin alpha 4 beta 7/LPAM-1 in Human PBMC by Flow Cytometry. Human PBMC were stained with (A) Human Anti-Human Integrin alpha 4 beta 7/LPAM-1 (Research Grade Vedolizumab Biosimilar) PE-conjugated Monoclonal Antibody (Catalog # FAB10078P) or (B) no primary antibody, followed by Mouse anti-Human CD3 APC-conjugated Monoclonal Antibody (Catalog # FAB100A). View our protocol for Staining Membrane-associated Proteins.

Reconstitution Calculator

Reconstitution Calculator

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: Integrin alpha 4 beta 7/LPAM-1

Vedolizumab is a biosimilar that binds and blocks binds to integrin alpha 4 beta 7. This product can be used in flow cytometry or various assay formats to block or measure integrin alpha 4 beta 7.

Entrez Gene IDs
3676 (Human); 16402 (Mouse)
Alternate Names
269C wild type; CD49 antigen-like family member D; CD49d antigen; CD49d; CD49d/beta7; CD49Dantigen CD49D, alpha-4 subunit of VLA-4 receptor; IA4; Integrin alpha 4 beta 7; integrin alpha 4; integrin alpha-4 subunit; integrin alpha-4; Integrin alpha-IV; integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor); LPAM1; LPAM-1; MGC90518; very late activation protein 4 receptor, alpha 4 subunit; VLA-4 subunit alpha

Product Datasheets

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FAQs

  1. What is the epitope of Human Integrin alpha 4 beta 7/LPAM-1 (Research Grade Vedolizumab Biosimilar) Antibody, Catalog # MAB10078? 

    • We have not mapped the epitope of this Biosimilar antibody, but the variable sequence is the same as the therapeutic antibody Vedolizumab.  According to the following literature, Vedolizumab binds to the extracellular portion of Integrin beta 7: https://academic.oup.com/ecco-jcc/article/10/12/1437/2706991, and https://rupress.org/jcb/article/196/1/131/36697.

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