Human ITM2C Antibody
Human ITM2C Antibody Summary
Accession # Q9NQX7
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Detection of Human ITM2C by Western Blot. Western blot shows lysates of JEG-3 human epithelial choriocarcinoma cell line and human brain tissue. PVDF membrane was probed with 1 µg/mL of Sheep Anti-Human ITM2C Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4904) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016). A specific band was detected for ITM2C at approximately 35-36 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
ITM2C (Integral membrane protein 2C; also BRI3 and cerebral protein 14) is a 36‑38 kDa member of the BRI3 family of proteins. It is found on neurons and appears to interact with APP, where ITM2C binding blocks proteolytic processing of APP, plus SCG10, where ITM2C binding blocks the microtubule-destabilizing activity of SCG10, thus inhibiting neurite outgrowth. Human ITM2C is a 267 amino acid (aa) type II transmembrane glycoprotein. Proteolytic cleavage by furin at Arg242Gly243 may create a truncated 34‑35 kDa ITM2C plus a C-terminal 4 kDa active peptide (aa 243‑267). The ECD (aa 76‑267) contains one BRICHOS domain (aa 136‑230). ITM2C may exist as a dimer. There are two splice variants, one that shows a deletion of aa 41‑87, and a second that shows a deletion of aa 151‑187. Over aa 86‑267, human ITM2C shares 96% aa identity with mouse ITM2C.
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