|Detection of Human KLF17 by Western Blot. Western blot shows lysates of human testis tissue. PVDF membrane was probed with 1 µg/mL of Sheep Anti-Human KLF17 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6845) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016). A specific band was detected for KLF17 at approximately 37 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8.|
KLF17 (Kruppel-like factor 17) is a 38-39 kDa member of the Sp1 C2H2-type zinc-finger protein family. Based on mouse studies, it is expressed in germ cells and likely plays a role in spermatid and oocyte differentiation. It is also found to be downregulated in tumors where, if present, it normally suppresses Id1 (Inhibitor of DNA binding 1), a transcription factor associated with tumorigenesis. Human KLF17 is 389 amino acids (aa) in length and contains three zinc-finger motifs (aa 283‑365). There is one potential alternate splice form that shows a 19 aa substitution for aa 97-389. Over aa 1-228, human KLF17 shares only 33% aa identity with mouse ZFP393/KLF17.
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