Human MAGP‑2/MFAP5 Biotinylated Antibody

MAGP-2 (Microfibril-associated glycoprotein 2; also MFAP-5) is a 25 kDa member of the MFAP family of proteins. It is secreted by smooth muscle cells and has multiple functions. Through its binding to EGF repeats, MAGP-2 mediates the release of Jagged1 and Notch extracellular domains, and also binds to matrix microfibrillar proteins, inducing elastin fiber formation. Mature human MAGP-2 is 152 amino acids (aa) in length. It contains an RDG motif (aa 30‑32) and a central Cys-rich domain (aa 84‑140) that participates in covalent binding to fibrillin microfibrils. One potential splice variant exists that shows a 10 aa deletion between aa 73‑82. Mature human MAGP-2 is 86% and 87% aa identical to mouse and canine MAGP-2, respectively.