Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunocytochemistry

Label

Alexa Fluor Plus 680 (Excitation = 687 nm, Emission = 704 nm)

Antibody Source

Monoclonal Mouse IgG1 Clone # 1075034
View all METTL3 Primary Antibodies »

Product Specifications

Immunogen

METTL3 containing Synthetic Peptide

Specificity

Detects human METTL3.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications for Human METTL3 Alexa Fluor™ Plus 680‑conjugated Antibody

Application
Recommended Usage

Immunocytochemistry

Optimal dilution of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: METTL3

METTL3 is a 70 kDa subunit and is the sole catalytic subunit in the methyltransferase complex which catalyzes N6-methyladenosine.  N6-methlyladenosine is the most abundant mRNA modification.  The full-length METTL3 protein consists of 580 amino acids. METTL3 plays a key role in a variety of cancers and expression is dysregulated via different mechanisms.  It plays a critical role in tumorigenesis, tumor growth, metastasis, metabolic reprogramming, immune cell infiltration, and tumor drug resistance. METTL3 can be an oncogene through depositing m6A modifications on critical transcripts.  In some cases, it can also be a tumor suppressor possibly by promoting cell cycle arrest in the G1 phase.

References

  1. Zeng C, Huang W, Li Y, Weng H. Roles of METTL3 in cancer: mechanisms and therapeutic targeting. J Hematol Oncol. 2020 Aug 27;13(1):117. doi: 10.1186/s13045-020-00951-w. PMID: 32854717; PMCID: PMC7457244. 
  2. Jin Q, Qu H, Quan C. New insights into the regulation of METTL3 and its role in tumors. Cell Commun Signal. 2023 Nov 23;21(1):334. doi: 10.1186/s12964-023-01360-5. PMID: 37996892; PMCID: PMC10732098.

Long Name

Methyltransferase like 3

Alternate Names

adoMet-binding subunit of the human mRNA (N6-adeno, hMETTL3, IME4, mRNA m(6)A methyltransferase, MT-A70, N6-adenosine-methyltransferase 70 kDa subunit, N6-adenosine-methyltransferase catalytic subunit, Spo8

Entrez Gene IDs

56339 (Human); 56335 (Mouse); 361035 (Rat)

Gene Symbol

Q86U44

UniProt

Q86U44 (Human)

Additional METTL3 Products

Product Documents for Human METTL3 Alexa Fluor™ Plus 680‑conjugated Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human METTL3 Alexa Fluor™ Plus 680‑conjugated Antibody


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

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Protocols

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FAQs

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