Human mGluR1a Antibody

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Product Details
Citations (1)
Supplemental Products

Human mGluR1a Antibody Summary

Species Reactivity
Detects human mGluR1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 5% cross-reactivity with recombinant human (rh) mGluR4, rhmGluR8, rhmGluR2, rhmGluR3 and rhmGluR7 is observed.
Polyclonal Sheep IgG
Antigen Affinity-purified
Chinese hamster ovary cell line CHO-derived recombinant human mGluR1
Accession # Q13255
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.


Recommended Concentration
Western Blot
0.1 µg/mL
Recombinant Human mGluR1a

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Preparation and Storage

Reconstitute at 0.2 mg/mL in sterile PBS.
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: mGluR1

Metabotropic glutamate receptor 1 (mGluR1) is a 130 kDa, 7-transmembrane glycoprotein that belongs to group I of the C-family of G-protein coupled receptors. On neurons, mGluR1 is postsynaptic, associates with Gq-like proteins, mobilizes intracellular Ca++, and influences ion channel activity. Mature mGluR1 is 1176 amino acids (aa) in length and contains a 574 aa N-terminal extracellular domain (ECD) (aa 19‑592). The ECD binds glutamate and forms either a covalent homodimer or heterodimer with CaSR. There is one alternative splice form for human mGluR1 that shows a 20 aa substitution for the C-terminal 308 amino acids. Over aa 33‑522, human mGluR1 shares more that 98% aa identity with mouse, rat and canine mGluR1.

Long Name
Metabotropic Glutamate Receptor 1
Entrez Gene IDs
2911 (Human); 14816 (Mouse); 24414 (Rat)
Alternate Names
glutamate receptor, metabotropic 1; GPRC1A; GRM1; GRM1A; metabotropic glutamate receptor 1; mGluR1; MGLUR1A; MGLUR1GPRC1AmGlu1

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Citation for Human mGluR1a Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

  1. Activation of Grm1 expression by mutated BRaf (V600E)in vitroandin vivo
    Authors: HC Chen, J Sierra, LJ Yu, R Cerchio, BA Wall, J Goydos, S Chen
    Oncotarget, 2017-12-23;9(5):5861-5875.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr


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