Human MICA APC-conjugated Antibody
Human MICA APC-conjugated Antibody Summary
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of MICA in K562 Human Cell Line by Flow Cytometry. K562 human chronic myelogenous leukemia cell line was stained with Mouse Anti-Human MICA APC-conjugated Monoclonal Antibody (Catalog # FAB1300A, filled histogram) or isotype control antibody (Catalog # IC0041A, open histogram). View our protocol for Staining Membrane-associated Proteins.
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Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: MICA
MICA (MHC class I chain-related gene A) is a transmembrane glycoprotein that functions as a ligand for human NKG2D. A closely related protein, MICB, shares 85% amino acid identity with MICA. These proteins are distantly related to the MHC class I proteins. They possess three extracellular Ig-like domains, but they have no capacity to bind peptide or interact with beta 2-microglobulin. The genes encoding these proteins are found within the Major Histocompatibility Complex on human chromosome 6. The MICA locus is highly polymorphic with more than 50 recognized human alleles. MICA is absent from most cells but is frequently expressed in epithelial tumors and can be induced by bacterial and viral infections. MICA is a ligand for human NKG2D, an activating receptor expressed on NK cells, NKT cells, gamma δ T cells, and CD8+ alpha beta T cells. Recognition of MICA by NKG2D results in the activation of cytolytic activity and/or cytokine production by these effector cells. MICA recognition is involved in tumor surveillance, viral infections, and autoimmune diseases.
Product Datasheets
Citations for Human MICA APC-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 8
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Immunomodulatory effect of NEDD8-activating enzyme inhibition in Multiple Myeloma: upregulation of NKG2D ligands and sensitization to Natural Killer cell recognition
Authors: S Petillo, C Capuano, R Molfetta, C Fionda, A Mekhloufi, C Pighi, F Antonangel, A Zingoni, A Soriani, MT Petrucci, R Galandrini, R Paolini, A Santoni, M Cippitelli
Cell Death & Disease, 2021;12(9):836.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Expression of ligands for activating natural killer cell receptors on cell lines commonly used to assess natural killer cell function
Authors: A Tremblay-M, S Coenraads, Z Kiani, FP Dupuy, NF Bernard
BMC Immunol., 2019;20(1):8.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Complete Remission with Reduction of High-risk Clones following Haploidentical NK Cell Therapy against MDS and AML
Authors: AT Björklund, M Carlsten, E Sohlberg, LL Liu, T Clancy, M Karimi, S Cooley, JS Miller, M Klimkowska, M Schaffer, E Watz, KI Wikstrom, P Blomberg, BE Wahlin, M Palma, L Hansson, P Ljungman, E Hellström-, HG Ljunggren, KJ Malmberg
Clin. Cancer Res., 2018;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Expression Profiles of Ligands for Activating Natural Killer Cell Receptors on HIV Infected and Uninfected CD4? T Cells
Authors: A Tremblay-M, J Bruneau, B Lebouché, I Lisovsky, R Song, NF Bernard
Viruses, 2017;9(10):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Modulation of NKG2D ligand expression and metastasis in tumors by spironolactone via RXRgamma activation.
Authors: Leung W, Vong Q, Lin W, Janke L, Chen T, Leung W
J Exp Med, 2013;210(12):2675-92.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Kaposi's sarcoma-associated herpesvirus ORF54/dUTPase downregulates a ligand for the NK activating receptor NKp44.
Authors: Madrid, Alexis S, Ganem, Don
J Virol, 2012;86(16):8693-704.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Biomarkers on melanoma patient T cells associated with ipilimumab treatment.
Authors: Wang W, Yu D, Sarnaik A, Yu B, Hall M, Morelli D, Zhang Y, Zhao X, Weber J
J Transl Med, 2012;10(0):146.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Expression of the ULBP ligands for NKG2D by B-NHL cells plays an important role in determining their susceptibility to rituximab-induced ADCC.
Authors: Inagaki A, Ishida T, Yano H, Ishii T, Kusumoto S, Ito A, Ri M, Mori F, Ding J, Komatsu H, Iida S, Ueda R
Int. J. Cancer, 2009;125(1):212-21.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
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