Human/Mouse HIF-1 alpha ExactaChIP Chromatin IP Kit
Human/Mouse HIF-1 alpha ExactaChIP Chromatin IP Kit Summary
The hypoxia-inducible transcription factor 1 alpha (HIF-1 alpha/HIF1A) is the regulated member of the transcription factor heterodimer HIF-1 alpha/beta. HIF-1 alpha/HIF1A binds to hypoxia-response elements (HREs) in the promoters of many genes involved in the adaptation to an environment of insufficient oxygen or hypoxia. Hypoxic tissue environments occur in vascular and pulmonary diseases as well as cancer, which illustrates the broad impact of gene regulation by HIF1A.
Background: HIF-1 alpha/HIF1A
Citations for Human/Mouse HIF-1 alpha ExactaChIP Chromatin IP Kit
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Inactivation of the HIF-1alpha/PDK3 signaling axis drives melanoma toward mitochondrial oxidative metabolism and potentiates the therapeutic activity of pro-oxidants.
Authors: Kluza J, Corazao-Rozas P, Touil Y, Jendoubi M, Maire C, Guerreschi P, Jonneaux A, Ballot C, Balayssac S, Valable S, Corroyer-Dulmont A, Bernaudin M, Malet-Martino M, de Lassalle E, Maboudou P, Formstecher P, Polakowska R, Mortier L, Marchetti P
Cancer Res, 2102;72(19):5035-47. 2102
RUNX1 mutations promote leukemogenesis of myeloid malignancies in ASXL1-mutated leukemia
Authors: R Bera, MC Chiu, YJ Huang, TH Lin, MC Kuo, LY Shih
J Hematol Oncol, 2019;12(1):104. 2019
Oligodendrocyte-encoded HIF function couples postnatal myelination and white matter angiogenesis.
Authors: Yuen T, Silbereis J, Griveau A, Chang S, Daneman R, Fancy S, Zahed H, Maltepe E, Rowitch D
Cell, 2014;158(2):383-96. 2014
Carnosine inhibits carbonic anhydrase IX-mediated extracellular acidosis and suppresses growth of HeLa tumor xenografts.
Authors: Ditte Z, Ditte P, Labudova M, Simko V, Iuliano F, Zatovicova M, Csaderova L, Pastorekova S, Pastorek J
BMC Cancer, 2014;14(0):358. 2014
HIF-1-mediated up-regulation of cardiotrophin-1 is involved in the survival response of cardiomyocytes to hypoxia.
Authors: Robador PA, San Jose G, Rodriguez C, Guadall A, Moreno MU, Beaumont J, Fortuno A, Diez J, Martinez-Gonzalez J, Zalba G
Cardiovasc. Res., 2011;92(2):247-55. 2011
Hypoxia stimulates low-density lipoprotein receptor-related protein-1 expression through hypoxia-inducible factor-1alpha in human vascular smooth muscle cells.
Authors: Castellano J, Aledo R, Sendra J, Costales P, Juan-Babot O, Badimon L, Llorente-Cortes V
Arterioscler. Thromb. Vasc. Biol., 2011;31(6):1411-20. 2011
Fibulin-5 Is Up-regulated by Hypoxia in Endothelial Cells through a Hypoxia-inducible Factor-1 (HIF-1 alpha)-dependent Mechanism.
Authors: Guadall A, Orriols M, Rodriguez-Calvo R, Calvayrac O, Crespo J, Aledo R, Martinez-Gonzalez J, Rodriguez C
J. Biol. Chem., 2011;286(9):7093-103. 2011
The hypoxia-inducible factor 1/NOR-1 axis regulates the survival response of endothelial cells to hypoxia.
Authors: Martorell L, Gentile M, Rius J, Rodriguez C, Crespo J, Badimon L, Martinez-Gonzalez J
Mol. Cell. Biol., 2009;29(21):5828-42. 2009
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