Human/Mouse HIF-1 alpha ExactaChIP Chromatin IP Kit

Discontinued Product

ECP1935 has been discontinued.
View all HIF-1 alpha/HIF1A products.
Product Details
Citations (8)
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Human/Mouse HIF-1 alpha ExactaChIP Chromatin IP Kit Summary

The hypoxia-inducible transcription factor 1 alpha (HIF-1 alpha/HIF1A) is the regulated member of the transcription factor heterodimer HIF-1 alpha/beta. HIF-1 alpha/HIF1A binds to hypoxia-response elements (HREs) in the promoters of many genes involved in the adaptation to an environment of insufficient oxygen or hypoxia. Hypoxic tissue environments occur in vascular and pulmonary diseases as well as cancer, which illustrates the broad impact of gene regulation by HIF1A.

Specifications

Storage
Store the unopened product at 2 - 8° C for up to 6 months from the date of receipt. Do not use past expiration date.
Applications
Chromatin Immunoprecipitation (ChIP)
Species
Human Mouse

Product Datasheets

Background: HIF-1 alpha/HIF1A

Long Name
Hypoxia Inducible Factor 1 Subunit Alpha
Entrez Gene IDs
3091 (Human); 15251 (Mouse); 29560 (Rat)
Alternate Names
AINT; anti-HIF-1 alpha; anti-HIF1A; ARNT interacting protein; ARNT-interacting protein; Basic-helix-loop-helix-PAS protein MOP1; BHLHE78; Class E basic helix-loop-helix protein 78; HIF 1A; HIF1 alpha; HIF-1 alpha; HIF1; HIF1A; HIF-1a; HIF-1alpha; HIF-1-alpha; HIF1-alpha; hypoxia inducible factor 1 alpha subunit, hypoxia inducible factor 1 subunit alpha; hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia-inducible factor 1-alpha; Member of PAS protein 1; member of PAS superfamily 1; MOP1; PAS domain-containing protein 8; PASD8

Reagents Provided

Citations for Human/Mouse HIF-1 alpha ExactaChIP Chromatin IP Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

8 Citations: Showing 1 - 8
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  1. Inactivation of the HIF-1alpha/PDK3 signaling axis drives melanoma toward mitochondrial oxidative metabolism and potentiates the therapeutic activity of pro-oxidants.
    Authors: Kluza J, Corazao-Rozas P, Touil Y, Jendoubi M, Maire C, Guerreschi P, Jonneaux A, Ballot C, Balayssac S, Valable S, Corroyer-Dulmont A, Bernaudin M, Malet-Martino M, de Lassalle E, Maboudou P, Formstecher P, Polakowska R, Mortier L, Marchetti P
    Cancer Res, 2102;72(19):5035-47.  2102
  2. RUNX1 mutations promote leukemogenesis of myeloid malignancies in ASXL1-mutated leukemia
    Authors: R Bera, MC Chiu, YJ Huang, TH Lin, MC Kuo, LY Shih
    J Hematol Oncol, 2019;12(1):104.  2019
  3. Oligodendrocyte-encoded HIF function couples postnatal myelination and white matter angiogenesis.
    Authors: Yuen T, Silbereis J, Griveau A, Chang S, Daneman R, Fancy S, Zahed H, Maltepe E, Rowitch D
    Cell, 2014;158(2):383-96.  2014
  4. Carnosine inhibits carbonic anhydrase IX-mediated extracellular acidosis and suppresses growth of HeLa tumor xenografts.
    Authors: Ditte Z, Ditte P, Labudova M, Simko V, Iuliano F, Zatovicova M, Csaderova L, Pastorekova S, Pastorek J
    BMC Cancer, 2014;14(0):358.  2014
  5. HIF-1-mediated up-regulation of cardiotrophin-1 is involved in the survival response of cardiomyocytes to hypoxia.
    Authors: Robador PA, San Jose G, Rodriguez C, Guadall A, Moreno MU, Beaumont J, Fortuno A, Diez J, Martinez-Gonzalez J, Zalba G
    Cardiovasc. Res., 2011;92(2):247-55.  2011
  6. Hypoxia stimulates low-density lipoprotein receptor-related protein-1 expression through hypoxia-inducible factor-1alpha in human vascular smooth muscle cells.
    Authors: Castellano J, Aledo R, Sendra J, Costales P, Juan-Babot O, Badimon L, Llorente-Cortes V
    Arterioscler. Thromb. Vasc. Biol., 2011;31(6):1411-20.  2011
  7. Fibulin-5 Is Up-regulated by Hypoxia in Endothelial Cells through a Hypoxia-inducible Factor-1 (HIF-1 alpha)-dependent Mechanism.
    Authors: Guadall A, Orriols M, Rodriguez-Calvo R, Calvayrac O, Crespo J, Aledo R, Martinez-Gonzalez J, Rodriguez C
    J. Biol. Chem., 2011;286(9):7093-103.  2011
  8. The hypoxia-inducible factor 1/NOR-1 axis regulates the survival response of endothelial cells to hypoxia.
    Authors: Martorell L, Gentile M, Rius J, Rodriguez C, Crespo J, Badimon L, Martinez-Gonzalez J
    Mol. Cell. Biol., 2009;29(21):5828-42.  2009

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