Human/Mouse NGFRAP1/BEX3 Alexa Fluor® 647-conjugated Antibody

Catalog #: FAB6858R Datasheet / COA / SDS

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FAB6858R-100UG

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All NGFRAP1/BEX3 Antibodies

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Human/Mouse NGFRAP1/BEX3 Alexa Fluor® 647-conjugated Antibody Summary

Species Reactivity

Human, Mouse

Specificity

Detects human NGFRAP1/BEX3 in direct ELISAs.

Source

Monoclonal Mouse IgG2b Clone # 672911

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human NGFRAP1/BEX3
Met1-Pro111
Accession # Q00994

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 647 (Excitation= 650 nm, Emission= 668 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: NGFRAP1/BEX3

NGFRAP1 (nerve growth factor receptor associated protein 1), also called BEX3 (brain-expressed X-linked protein 3), NADE (p75NTR-associated death executor) or FAP-1 (Fas-associated phosphatase-1), is a 24 kDa member of the BEX protein family. A nuclear export signal (aa 77-87) allows NGFRAP1 to export bound p75NTR. It is widely expressed, but highest in ovarian granulosa cells, testis, prostate, seminal vesicle and liver. Except for a 13-19 amino acid (aa) rodent Arg/His region at aa 35 that is not found in humans, human NGFRAP1 shares 94% aa identity with mouse and rat NGFRAP1. In humans, a 101 aa isoform with an alternative start site at aa 11 has been described.

Long Name

Nerve Growth Factor Receptor Associated Protein 1

Entrez Gene IDs

27018 (Human); 12070 (Mouse); 117089 (Rat)

Alternate Names

BEX3; BEX3p75NTR-associated cell death executor; Brain-expressed X-linked protein 3; DXS6984EX-linked 3; HGR74; NADE; nerve growth factor receptor (TNFRSF16) associated protein 1; Nerve growth factor receptor-associated protein 1; NGFRAP1; Ovarian granulosa cell 13.0 kDa protein HGR74; ovarian granulosa cell protein (13kD); protein BEX3