Human/Mouse PLC-beta 1 Alexa Fluor® 647-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: PLC-beta 1

The Phospholipase C family consists of 13 isozymes within six subfamilies, PLC-δ, -beta, -gamma, -epsilon, -zeta, and -eta. PLC-beta 1 (Phospholipase C beta-1) is a G-protein dependent phosphodiesterase that catalyzes the generation of inositol 1, 4, 5-trisphosphate (IP3) and diacylglycerol (DAG) from phosphatidylinositol 4, 5-bisphosphate (IP2), an essential step in the intracellular transduction of many extracellular signals. Alternative splicing results in two transcript variants encoding two isoforms, PLC-beta 1A and PLC-beta 1B. PLC-beta 1A is preferentially expressed in the cytosol, while PLC-beta 1B is predominantly expressed in the nucleus. The region used as immunogen is 100% identical in both isoforms.

Product Datasheets

Related Research Areas

• Bioactive Lipids and Receptors
• Chemokine Receptor Intracellular Signaling
• GDNF Family
• Intracellular Calcium Signaling in VSMC
• Lipid/Cholesterol Metabolism Enzymes
• Neurotrophin/Trk Family
• Phospholipases, Small GTPases, and Other Molecules in the Akt Pathway
• Platelet Signaling
• Steroid Hormones and Bioactive Lipids