Human/Mouse/Rat CaM Kinase II Pan Specific Alexa Fluor® 700-conjugated Antibody

Catalog #: FAB7280N Datasheet / COA / SDS

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FAB7280N-100UG

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Human/Mouse/Rat CaM Kinase II Pan Specific Alexa Fluor® 700-conjugated Antibody Summary

Species Reactivity

Human, Mouse, Rat

Specificity

Detects human CaM Kinase II gamma in direct ELISAs. Detects human CaM Kinase II alpha, beta, gamma, and δ in Western blots. Detects human, mouse, and rat CaM Kinase II in Western blots.

Source

Monoclonal Mouse IgG2b Clone # 990714

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human CaM Kinase II Î³
Ala448-Gln558
Accession # Q13555

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 700 (Excitation= 675-700 nm, Emission= 723 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Immunocytochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: CaM Kinase II

Calcium/calmodulin-dependent protein kinase type II gamma (CaMKII gamma ) belongs to a family of multifunctional serine/threonine kinases activated in response to increases in intracellular calcium. There are 4 CaMKII isozymes, alpha, beta, gamma, and δ, and each can yield several isoforms through alternative splicing. CaMKII isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. The widely expressed CaMKII gamma from human, mouse, and rat share 100% aa sequence identity within aa 448-558 of isoform 1.

Long Name

Calcium/Calmodulin-dependent Protein Kinase II

Alternate Names

Calcium/calmodulin-dependent protein kinase;Calcium/calmodulin-dependent protein kinase type II subunit beta;CAM2;CAMK2;CAMK2B;CAMKB;CaMKIIbeta;MRD54; CaM Kinase II; CAMK2; CAMK2B