Human/Mouse/Rat CUGBP1/CELF1 Alexa Fluor® 594-conjugated Antibody

Catalog #: FAB9388T Datasheet / COA / SDS

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FAB9388T-100UG

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All CUGBP1/CELF1 Antibodies

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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human/Mouse/Rat CUGBP1/CELF1 Alexa Fluor® 594-conjugated Antibody Summary

Species Reactivity

Human, Mouse, Rat

Specificity

Detects human CUGBP1/CELF1 in direct ELISAs and Western blots.

Source

Monoclonal Mouse IgG2b Clone # 850717

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human CUGBP1/CELF1
Met1-Gly60
Accession # Q92879

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 594 (Excitation= 590 nm, Emission= 617 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: CUGBP1/CELF1

CELF-1 is a highly conserved, ubiquitous protein which binds pre-mRNA in the nucleus to mediate alternative splicing to produce alternative transcripts in tissue-specific and developmentally regulated events. In the cytoplasm, CELF-1 binds to GRE-containing transcripts which are rapidly degraded. Additionally, cytoplasmic CELF-1 binds to untranslated regions of transcripts for stability and translation efficiency. Many transcripts targeted by CELF-1 show rapid up-regulation leading to cellular activation or proliferation, while others show down-regulation. CELF-1 has also been shown to localize to cytoplasmic stress granules when cells are stressed. This gene is associated with myotonic dystrophy type 1 (DM1) disease though interactions with the dystrophia myotnica-protein kinase (DMPK) gene.

Long Name

CUGBP, Elav-Like Family Member 1

Entrez Gene IDs

10658 (Human); 13046 (Mouse); 362160 (Rat)

Alternate Names

BRUNOL2; BRUNOL250 kDa nuclear polyadenylated RNA-binding protein; bruno-like 2; Bruno-like protein 2; CELF1; CUG RNA-binding protein; CUG triplet repeat, RNA binding protein 1; CUG triplet repeat, RNA-binding protein 1; CUG-BP- and ETR-3-like factor 1; CUGBP Elav-like family member 1; CUG-BP; CUGBP, Elav-like family member 1; CUGBP1; CUG-BP1; CUGBP1CUG triplet repeat RNA-binding protein 1; CUGBPCELF-1; D2Wsu101e; Deadenylation factor CUG-BP; EDEN-BP homolog; EDEN-BP; embryo deadenylation element binding protein; Embryo deadenylation element-binding protein homolog; HNAB50; NAB50; NAB50CUG-BP1; NAPOR; nuclear polyadenylated RNA-binding protein, 50-kD; RNA-binding protein BRUNOL-2