Human/Mouse/Rat STAT6 aa 627-838 Alexa Fluor® 532-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: STAT6

Signal Transducer and Activator of Transcription 6 (STAT6) is a member of the Jak/STAT signal transduction pathway and mediates cytokine signaling by IL-4. IL-4 activation leads to tyrosine phosphorylation and accumulation in the nucleus of STAT6 homo and heterodimers. STAT6 acts as a signal transducer in the cytoplasm and, upon phosphorylation at Y641, translocates to the nucleus and binds to the DNA consensus site TTCN₄GAA. Knockout studies in mice suggest that STAT6 functions in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. STAT6 transcriptional activation occurs by binding p100 and p160 class (NcoA1, Src-1) co-activators. Gene expression studies indicate that STAT6 mediates cell proliferation and anti-apoptotic effects of IL-4.

Product Datasheets

Related Research Areas

• Apoptosis Transcription Factors and Regulators
• Common gamma Chain Receptor Family
• Hematopoietic Stem Cell Transcription Factors and Regulators
• Immunoglobulin-Like Domain Transcription Factors
• Interferons
• Jak and STAT Proteins
• Macrophage Activation Markers
• Myeloid-derived Suppressor Cells (MDSC)
• PDGF Family
• STAT
• Th2 Cells
• Th9 Cells
• Transcriptional Regulators in Allergy and Asthma