Human/Mouse STAT5a/b Pan Specific Alexa Fluor® 405-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: STAT5a

Signal transduction and activator of transcription 5 (STAT5) is a member of the Jak/STAT signal transduction pathway and is activated by a variety of cytokines (IL22, IL6, IFN-α). STAT5 has two isoforms (A and B) that share 93% amino acid identity and bind the DNA consensus site TTCN3GAA. STAT5 mediates cytokine signaling by acting as a signal transducer in the cytoplasm and, upon phosphorylation, translocates to the nucleus and activates transcription of specific genes. STAT5 is involved in a wide array of biological processes ranging from regulating apoptosis to adult mammary gland proliferation, differentiation and survival.

Product Datasheets

Related Research Areas

• Apoptosis Transcription Factors and Regulators
• Cancer Stem Cell Transcription Factors
• Common gamma Chain Receptor Family
• Hematopoietic Stem Cell Markers
• Hematopoietic Stem Cell Transcription Factors and Regulators
• IL-10 and Interferon Family Regulators
• IL-10 Family
• IL-12 Family
• Immunoglobulin-Like Domain Transcription Factors
• Interferons
• Jak and STAT Proteins
• PDGF Family
• Regulatory T Cells (Tregs)
• STAT
• Th2 Cells
• Transcription Factors in the Akt Pathway
• Transcriptional Regulators in Allergy and Asthma