Human MSX2 Alexa Fluor® 488-conjugated Antibody

Catalog #: FAB7917G Datasheet / COA / SDS

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FAB7917G-100UG

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Human MSX2 Alexa Fluor® 488-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human MSX2 in ELISAs. In direct ELISAs, no cross-reactivity with recombinant human MSX1 is observed.

Source

Monoclonal Mouse IgG1 Clone # 786607

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human MSX2
Ala2-Thr132
Accession # P35548

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 488 (Excitation= 488 nm, Emission= 515-545 nm)

Applications

Recommended Concentration

Sample

Immunocytochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: MSX2

MSX2, also known as HOX-8, is an approximately 35 kDa homeobox transcription factor that is a downstream target of canonical Wnt signaling. MSX2 plays an important role in the development of mineralized tissues including bone, cartilage, and teeth. It is upregulated in atherosclerotic plaques and promotes the calcification of vascular smooth muscle cells during inflammation. MSX2 suppresses the adipocytic differentiation of multipotent mesenchymal cells. MSX2 acts in mammary gland development and the initiation of female fetal germ cell meiosis. It promotes tumorigenesis of breast and pancreatic carcinomas but inhibits the survival and invasiveness of melanoma cells. Human MSX2 contains one homeodomain (aa 143-201). Within aa 1-132, human MSX2 shares 87% aa sequence identity with mouse and rat MSX2.

Long Name

Msh Homeobox 2

Entrez Gene IDs

4488 (Human); 17702 (Mouse); 25483 (Rat)

Alternate Names

CRS2; CRS2parietal foramina 1; FPP; Homeobox protein Hox-8; homeobox protein MSX-2; Hox8; HOX8msh homeobox homolog 2 (Drosophila); msh (Drosophila) homeo box homolog 2; msh homeo box 2; msh homeobox 2; msh homeobox homolog 2; MSH; MSX2; PFM; PFM1