Human NKG2C/CD159c Alexa Fluor® 488-conjugated Antibody

Catalog # Availability Size / Price Qty
FAB1381G-100UG
Detection of  NKG2C/CD159c in Human Blood Lymphocytes by Flow Cytometry.
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Human NKG2C/CD159c Alexa Fluor® 488-conjugated Antibody Summary

Species Reactivity
Human
Specificity
Detects human NKG2C/CD159c. Detects human NKG2C/CD159c as part of the NKG2C/CD94 heterodimer in flow cytometry. No
cross-reactivity with the human NKG2A/CD94 heterodimer or with the human CD94 homodimer is detected.
Source
Monoclonal Mouse IgG2B Clone # 134522
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
BaF3 mouse pro-B cell line transfected with human NKG2C/CD159c and CD94
Formulation
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
Label
Alexa Fluor 488

Applications

Recommended Concentration
Sample
Flow Cytometry
0.25-1 µg/106 cells
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Data Example

Flow Cytometry Detection of  NKG2C/CD159c in Human Blood Lymphocytes by Flow Cytometry. View Larger

Detection of NKG2C/CD159c in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human NCAM‑1/CD56 APC‑conjugated Monoclonal Antibody (Catalog # FAB2408A) and either (A) Alexa Fluor® 488‑conjugated Mouse Anti-Human NKG2C/CD159c Monoclonal Antibody (Catalog # FAB1381G) or (B) Mouse IgG2B Flow Cytometry Isotype Control (Catalog # IC0041G).View our protocol for Staining Intracellular Molecules.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: NKG2C/CD159c

NKG2C, also known as hemoglobin scavenger receptor, is a type II transmembrane protein expressed exclusively in monocytes and macrophages. It is a scavenger receptor cysteine-rich superfamily (SRCR-SF) protein that contains nine SRCR motifs in its extracellular region. MAB1381 displays potent agonistic activity and also blocks the binding of the NKG2C/CD94 heterodimer to HLA-E tetramers (1-3).

References
  1. Alici, E. et al. (2008) Blood 111:3155.
  2. Coupel, S. et al. (2007) Blood 109:2806.
  3. Fausther-Bovendo, H. et al. (2008) AIDS 22:217.
Long Name
Natural Killer G2C
Entrez Gene IDs
3822 (Human); 16642 (Mouse)
Alternate Names
CD159 antigen-like family member C; CD159c antigen; CD159c; killer cell lectin-like receptor subfamily C, member 2; KLRC2; MGC138244; NK cell receptor C; NKG2-C type II integral membrane protein; NKG2C; NKG2-C; NKG2CNKG2-C-activating NK receptor

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