Human NKG2C/CD159c Alexa Fluor® 488-conjugated Antibody Summary
cross-reactivity with the human NKG2A/CD94 heterodimer or with the human CD94 homodimer is detected.
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Detection of NKG2C/CD159c in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human NCAM‑1/CD56 APC‑conjugated Monoclonal Antibody (Catalog # FAB2408A) and either (A) Alexa Fluor® 488‑conjugated Mouse Anti-Human NKG2C/CD159c Monoclonal Antibody (Catalog # FAB1381G) or (B) Mouse IgG2B Flow Cytometry Isotype Control (Catalog # IC0041G).View our protocol for Staining Intracellular Molecules.
Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
NKG2C, also known as hemoglobin scavenger receptor, is a type II transmembrane protein expressed exclusively in monocytes and macrophages. It is a scavenger receptor cysteine-rich superfamily (SRCR-SF) protein that contains nine SRCR motifs in its extracellular region. MAB1381 displays potent agonistic activity and also blocks the binding of the NKG2C/CD94 heterodimer to HLA-E tetramers (1-3).
- Alici, E. et al. (2008) Blood 111:3155.
- Coupel, S. et al. (2007) Blood 109:2806.
- Fausther-Bovendo, H. et al. (2008) AIDS 22:217.
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