Human p53 APC-conjugated Antibody
Human p53 APC-conjugated Antibody Summary
Asp7-Asp393
Accession # P04637
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of p53 in MCF‑7 Human Cell Line by Flow Cytometry. MCF-7 human breast cancer cell line treated (filled histogram) with camptothecin (CPT) or untreated (open histogram) was stained with Mouse Anti-Human p53 APC-conjugated Monoclonal Antibody (Catalog # IC13551A). To facilitate intracellular staining, cells were fixed with Flow Cytometry Fixation Buffer (Catalog # FC004) and permeabilized with Flow Cytometry Permeabilization/Wash Buffer I (Catalog # FC005). View our protocol for Staining Intracellular Molecules.
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Preparation and Storage
Background: p53
The p53 tumor suppressor protein is a multi-functional transcription factor that regulates cellular decisions regarding proliferation, cell cycle checkpoints, and apoptosis. The importance of p53 is underscored by its mutation in over 50% of human cancers. Mice that lack one or both copies of p53 also showed an increased incidence of tumors, which makes the p53 deficient mouse a model system for studying cancer generation and progression.
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