Human p63/TP73L Antibody

Name: Human p63/TP73L Antibody
Brand: R&D Systems
SKU: MAB1916

Catalog #: MAB1916 Datasheet / COA / SDS

Discontinued Product

MAB1916 has been discontinued.

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All p63/TP73L Antibodies

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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human p63/TP73L Antibody Summary

Species Reactivity

Human

Specificity

Detects human p63/TP73L in direct ELISAs. It is predicted to recognize all forms of p63, including TAp63, deltaNp63 and TP63 alpha, beta, gamma and δ.

Source

Monoclonal Mouse IgG_2B Clone # 241631

Purification

Protein A or G purified from hybridoma culture supernatant

Immunogen

E. coli-derived recombinant human p63/TP73L
Met1-Thr300
Accession # NP_003713

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.

Label

Unconjugated

Applications

Recommended Concentration

Sample

Immunocytochemistry

8-25 µg/mL

Immersion fixed SCC-25 human squamous cell sarcoma cell line

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: p63/TP73L

Tumor Protein 63 (p63), also named TP73L, TP63, p51, p40 or KET, is a p53 homolog. It is one of several proteins that are produced from a single gene using two promoters and alternative splicing of the primary RNA transcript. p63 is highly expressed in embryonic ectoderm and in the nuclei of basal regenerative cells of many epithelial tissues in the adult. p63 is suggested to play a role in development, epithelial cell maintenance and tumorigenesis (1‑3).

References

Harms, K. et al. (2004), Cell Mol. Life Sci. 61(7):822.
Koster, M.I. and D.R. Roop, J. Dermatol. Sci. 34(1):3.
Benard, J. et al. (2003) Hum. Mutat. 21(3):182.

Long Name

Tumor Protein 63

Entrez Gene IDs

8626 (Human)

Alternate Names

amplified in squamous cell carcinoma; Chronic ulcerative stomatitis protein; CUSP; EEC3; EEC3B(p51B); Keratinocyte transcription factor KET; KET; KETRHS; LMS; OFC8; OFC8SHFM4TP73LNBP; p40; p51; p51tumor protein p53-like; p53CP; p63; p63AIS; p73H; p73L; p73LB(p51A); SHFM4; TP53CP; TP53L; TP63; TP73L; Transformation-related protein 63; tumor protein 63; tumor protein p53-competing protein; tumor protein p63 deltaN isoform delta; tumor protein p63; Tumor protein p73-like