Human/Primate GDF-15 Biotinylated Antibody
Human/Primate GDF-15 Biotinylated Antibody Summary
Ala197-Ile308
Accession # Q99988
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Applications
Human/Primate GDF-15 Sandwich Immunoassay
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
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Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: GDF-15
Growth Differentiation Factor 15 (GDF-15), also called Macrophage inhibitory cytokine-1 (MIC-1), placental transforming growth factor-beta, prostate-derived factor, and placental bone morphogenetic protein, is a divergent member of the transforming growth factor beta (TGF-beta ) superfamily. GDF-15 is highly expressed in placenta and is expressed at lower levels in kidney, pancreas, prostate and colon. It is also widely expressed in brain. Similar to other TGF-beta family proteins, GDF-15 is synthesized as a large precursor protein that is cleaved at the dibasic cleavage site (RXXR) to release the carboxy-terminal domain. The carboxy-terminal domain of GDF-15 contains the characteristic seven conserved cysteine residues necessary for the formation of the cysteine knot and the single interchain disulfide bond. Furthermore, the carboxy-terminal domain contains two additional cysteine residues that form a fourth intrachain disulfide bond. Biologically active GDF-15 is a disulfide-linked homodimer of the carboxy-terminal 112 amino acid residues. Mature human GDF-15 shares 66.1% and 68.7% amino acid sequence similarity with rat and mouse GDF-15, respectively, which are remarkably low homologies between species in TGF-beta superfamily. GDF-15 has been shown to have various functions, including inhibition of production of tumor necrosis factor alpha (TNF-alpha ) from lipopolysaccharide-stimulated macrophages, induction of cartilage formation, early-stage endochonadal bone formation, and promotion of neuronal survival.
- Bootcov, M.R. et al. (1997) Proc. Natl. Acad. Sci. USA 94:11514.
- Böttner, M. et al. (1999) Gene 237:105.
- Fairlie, W.D. et al. (1998) J. Leukoc. Biol 65:2.
- Fairlie, W.D. et al. (2001) J B.C 20:16911.
- Bauskin, A.R. et al. (2000) EMBO J. 19:2212.
- Strelau, J. et al. (2000) J. Neurosci. 20:8597.
- Schober, A. et al. (2001) J. Comp. Neurol. 439:32.
Product Datasheets
Citations for Human/Primate GDF-15 Biotinylated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 6
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Circulating levels of GDF15 in patients with myalgic encephalomyelitis/chronic fatigue syndrome
Authors: A Melvin, E Lacerda, HM Dockrell, S O'Rahilly, L Nacul
J Transl Med, 2019;17(1):409.
Species: Human
Sample Types: Serum
Applications: ELISA Detection -
GDF15/MIC1 and MMP9 Cerebrospinal Fluid Levels in Parkinson's Disease and Lewy Body Dementia.
Authors: Walter Maetzler, Willy Deleersni, Valérie Hanssens, Alice Bernard, Kathrin Brockmann, Justus Marquetan, Isabel Wurster, Tim W Rattay, Lorenzo Roncoroni, Eva Schaeffer, Stefanie Lerche, Anja Apel, Christian Deuschle, Daniela Berg
PLoS ONE, 2016;0(0):1932-6203.
Species: Human
Sample Types: Beads
Applications: Luminex Development -
Macrophage inhibitory cytokine 1 biomarker serum immunoassay in combination with PSA is a more specific diagnostic tool for detection of prostate cancer.
Authors: Li, Ji, Veltri, Robert W, Yuan, Zhen, Christudass, Christhu, Mandecki, Wlodek
PLoS ONE, 2015;10(4):e0122249.
Species: Human
Sample Types: Serum
Applications: ELISA Development (Detection) -
AF1q: A Novel Mediator of Basal and 4-HPR-Induced Apoptosis in Ovarian Cancer Cells.
Authors: Tiberio P, Cavadini E, Callari M
PLoS ONE, 2012;7(6):e39968.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Growth differentiation factor-15 as a prognostic marker in patients with acute myocardial infarction.
Authors: Khan SQ, Ng K, Dhillon O, Kelly D, Quinn P, Squire IB, Davies JE, Ng LL
Eur. Heart J., 2009;30(9):1057-65.
Species: Human
Sample Types: Plasma
Applications: ELISA Development -
Growth differentiation factor-15 predicts mortality and morbidity after cardiac resynchronization therapy.
Authors: Foley PW, Stegemann B, Ng K, Ramachandran S, Proudler A, Frenneaux MP, Ng LL, Leyva F
Eur. Heart J., 2009;30(22):2749-57.
Species: Human
Sample Types: Plasma
Applications: ELISA Development
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Reviews for Human/Primate GDF-15 Biotinylated Antibody
Average Rating: 4 (Based on 2 Reviews)
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This antibody was used as the detection in an ELISA along with MAB957 as the capture antibody. Human serum and plasma samples were measurable.
This antibody was used as the pair to MAB957 in an GDF-15 immunoassay.
