Human/Rat Neuritin Antibody Summary
Accession # Q9NPD7
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Detection of Human Neuritin by Western Blot. Western blot shows lysates of human brain (cerebellum) tissue and human kidney tissue. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human/Rat Neuritin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF283) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF017). A specific band was detected for Neuritin at approximately 14 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Neuritin is a 14 kDa GPI-linked molecule that is expressed on developing and differentiating neurons as well as on hepatocytes. Neuritin is upregulated in response to BDNF, NT-3, androgens, and hypoxia, and it promotes neurite extension and arborization. Mature human Neuritin shares 99% and 100% aa sequence identity with mouse and rat Neuritin, respectively.
Citations for Human/Rat Neuritin Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
Citations: Showing 1 - 3
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Neuritin Upregulates Kv4.2 ?-subunit of Potassium Channel Expression and Affects Neuronal Excitability by Regulating the Calcium-Calcineurin-NFATc4 Signaling Pathway
Authors: Jin-Jing Yao
J Biol Chem, 2016;0(0):.
Sample Types: Tissue Homogenates
Neuritin attenuates cognitive function impairments in tg2576 mouse model of Alzheimer's disease.
Authors: Choi, Yoori, Lee, Kihwan, Ryu, Junghwa, Kim, Hyoun Ge, Jeong, A Young, Woo, Ran-Sook, Lee, Jun-Ho, Hyun, Jin Won, Hahn, Seokyung, Kim, Joung-Hu, Kim, Hye-Sun
PLoS ONE, 2014;9(8):e104121.
Sample Types: Whole Tissue
Applications: IHC Paraffin-embedded
Neuritin mediates nerve growth factor-induced axonal regeneration and is deficient in experimental diabetic neuropathy.
Authors: Karamoysoyli E, Burnand RC, Tomlinson DR, Gardiner NJ
Sample Types: Cell Lysates
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