Human/Rat Phospho-ATF2 (S490/S498) Antibody
Human/Rat Phospho-ATF2 (S490/S498) Antibody Summary
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
ATF2 (activating transcription factor 2; also CRE-BP1) is a 60 kDa member of the ATF subfamily, basic-region leucine zipper family of DNA binding proteins. It has at least two activities. First, it binds to an octameric palindromic CRE (cAMP response element) 5’-TGACGTCA-3’, and secondary, it shows histone acetyltransferase (HAT) activity towards histones H2B and H4. Its palindromic binding activity depends upon homodimerization, or heterodimerization with either c-Jun or CRE-Bpa. Human ATF2 is 505 amino acids (aa) in length, and contains a C2H2-type zinc finger segment (aa 25-49), a HAT region (aa 112-350), and a basic leucine zipper domain (aa 350-414). There are over a dozen alternate splice forms that, in their entirety, impact all segments of the molecule. ATF2 is phosphorylated at multiple sites, including S62/S90/S112/S340/S368/S490/S498 and T69/T71. The Thr phosphorylations increase transcriptional and HAT activity. Serine phosphorylations at S490/S498 by ATM contribute to DNA damage repair after ionizing radiation. Human ATF2 is greater that 95% aa identical to mouse ATF2 and 100% identical to rat ATF2.
- Maekawa, T. et al. (1989) EMBO J. 8:2023.
- Bailey, J. et al. (2002) J. Clin. Endocrinol. Metab. 87:1717.
- GenBank Accession # AAY17202-AAY17215.
- Morton, S. et al. (2004) FEBS Lett. 572:177.
- Kawasaki, H. et al. (2000) Nature 405:195.
- Bhoumik, A. et al. (2005) Mol. Cell 18:577.
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