Human Reg1A Antibody Summary
Accession # P05451
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Detection of Reg1A in AGS Human Cell Line by Flow Cytometry. AGS human gastric adenocarcinoma cell line was stained with Rat Anti-Human Reg1A Monoclonal Antibody (Catalog # MAB4937, filled histogram) or isotype control antibody (Catalog # MAB0061, open histogram), followed by Allophycocyanin-conjugated Anti-Rat IgG F(ab')2Secondary Antibody (Catalog # F0113). To facilitate intracellular staining, cells were fixed with paraformaldehyde and permeabilized with saponin.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Reg1A, also known as PTP, PSP, and lithostathine, is a member of the Reg family of secreted proteins with a C-type lectin domain. Due to variable glycosylation, pancreatic Reg1A exists as multiple species of 16‑18 kDa. Reg1A promotes the maintenance and growth of pancreatic islet beta -cells and intestinal villi. It is up‑regulated in pancreatitis and some carcinomas. Reg1A is an antigenic target in autoimmune diabetes. Human Reg1A shares 65%‑68% aa sequence identity with mouse and rat Reg1A.
Citation for Human Reg1A Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response
Authors: Y Haberman, R Karns, PJ Dexheimer, M Schirmer, J Somekh, I Jurickova, T Braun, E Novak, L Bauman, MH Collins, A Mo, MJ Rosen, E Bonkowski, N Gotman, A Marquis, M Nistel, PA Rufo, SS Baker, CG Sauer, J Markowitz, MD Pfefferkor, JR Rosh, BM Boyle, DR Mack, RN Baldassano, S Shah, NS Leleiko, MB Heyman, AM Grifiths, AS Patel, JD Noe, BJ Aronow, S Kugathasan, TD Walters, G Gibson, SD Thomas, K Mollen, S Shen-Orr, C Huttenhowe, RJ Xavier, JS Hyams, LA Denson
Nat Commun, 2019;10(1):38.
Sample Types: Whole Tissue
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