Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Sheep IgG
View all Serpin B6 Primary Antibodies »

Product Specifications

Immunogen

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Serpin B6
Asp2-Pro376
Accession # P35237

Specificity

Detects human Serpin B6 in direct ELISAs and Western blots. In direct ELISAs, less than 5% cross‑reactivity with recombinant human (rh) Serpin B8 and rhSerpin B9 is observed.

Clonality

Polyclonal

Host

Sheep

Isotype

IgG

Applications for Human Serpin B6 Antibody

Application
Recommended Usage

Western Blot

0.1 µg/mL
Sample: Recombinant Human Serpin B6

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Calculators

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: Serpin B6

Serpin B6 (serine protease inhibitor-clade B#6; also placental thrombin inhibitor) is a 42 kDa, cytosolic member of the ovalbumin (clade B)-subfamily, Serpin superfamily of protease inhibitors. It is produced by multiple cell types (keratinocytes; monocytes; mast cells), and shows inhibitory activity towards thrombin, plasmin and chymotrypsin. Human Serpin B6 is 376 amino acids (aa) in length. An active inhibitor site lies between Glu327 and Met338. Multiple potential isoforms exist. One shows a 28 aa substitution for the N-terminal 191 amino acids. Three others have alternate start sites that vary from 14‑33 aa’s upstream of the standard start site. Human Serpin B6 shares 76% aa identity with mouse Serpin B6.

Alternate Names

CAP, PI6, PTI

Entrez Gene IDs

5269 (Human); 20719 (Mouse); 291085 (Rat)

Gene Symbol

SERPINB6

UniProt

P35237

Additional Serpin B6 Products

Product Documents for Human Serpin B6 Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Note: Certificate of Analysis not available for kit components.

Download SDS

Product Specific Notices for Human Serpin B6 Antibody

For research use only

Related Research Areas

Serine Proteases and Regulators

Citations for Human Serpin B6 Antibody

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