Human SLC1A5 Antibody (1085750) [Alexa Fluor™ Plus 555]

R&D Systems | Catalog # FAB11603AFP555

R&D Systems

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Western Blot, Immunocytochemistry

Label

Alexa Fluor Plus 555 (Excitation = 558 nm, Emission = 572 nm)

Antibody Source

Monoclonal Mouse IgG2B Clone # 1085750
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Product Specifications

Immunogen

Synthetic Peptide

Specificity

Detects a synthetic peptide corresponding to residues near amino acid 500 of human SLC1A5 protein by Direct ELISA.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Applications for Human SLC1A5 Antibody (1085750) [Alexa Fluor™ Plus 555]

Application
Recommended Usage

Immunocytochemistry

Optimal dilution of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: SLC1A5

SLC1A5 is a sodium dependent antiporter also known as ASCT2 (ASC amino acid Transporter2).  It is a member of the solute carrier (SLC) superfamily of transporters and plays an important role in tumors.  It is one of the 3 proteins, including SLC7A5 and SLC3A2, that are among the highest differentially expressed genes in activated lymphocytes and cancerous cells.  Pharmacological inhibition of SLC1A5 was found to abrogate the effector functions of NK cells.  In a pancancer analysis of SLC1A5, it has been demonstrated to be a prognostic biomarker in cancer patients.

References

  1. Nachef M, Ali AK, Almutairi SM, Lee SH. Targeting SLC1A5 and SLC3A2/SLC7A5 as a Potential Strategy to Strengthen Anti-Tumor Immunity in the Tumor Microenvironment. Front Immunol. 2021 Apr 19;12:624324. doi: 10.3389/fimmu.2021.624324. PMID: 33953707; PMCID: PMC8089370. 
  2. Chen P, Jiang Y, Liang J, Cai J, Zhuo Y, Fan H, Yuan R, Cheng S, Zhang Y. SLC1A5 is a novel biomarker associated with ferroptosis and the tumor microenvironment: a pancancer analysis. Aging (Albany NY). 2023 Aug 10;15(15):7451-7475. doi: 10.18632/aging.204911. Epub 2023 Aug 10. PMID: 37566748; PMCID: PMC10457057.

Long Name

SLC1A5

Alternate Names

AAAT, ASCT2, ATBO, baboon M7 virus receptor, M7V1, M7VS1, R16, RD114 virus receptor, RDRC

Entrez Gene IDs

6510 (Human); 20514 (Mouse); 292657 (Rat)

Gene Symbol

Q15758

UniProt

Additional SLC1A5 Products

Product Documents for Human SLC1A5 Antibody (1085750) [Alexa Fluor™ Plus 555]

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human SLC1A5 Antibody (1085750) [Alexa Fluor™ Plus 555]


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

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Protocols

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