Human Smad2/3 ExactaChIP Chromatin IP Kit

Human Smad2/3 ExactaChIP Chromatin IP Kit Summary

Specifications

Product Datasheets

Background: Smad2/3

Smads are a family of intracellular proteins that mediate signaling by members of the TGF-beta superfamily. Smads are divided into three distinct subgroups based on their different roles in TGF-beta family signal transduction: R-Smads (receptor-regulated), Co-Smads (common partner), and I-Smads (inhibitory). In general, activation of TGF-beta superfamily serine/threonine kinase receptors leads to the phosphorylation of R-Smads (Smads1, 2, 3, 5, and 8). This is followed by recruitment of the Co-Smad (Smad-4) into an R-Smad/Co-Smad complex that translocates to the nucleus to regulate gene expression. I-Smads (Smad6 and Smad7) antagonize this signaling pathway by preventing R-Smads from interacting with the receptor, or by competing with Co-Smads for the generation of R-Smad/Co-Smad complexes.

Related Research Areas

• Airway Inflammation and Remodeling
• Embryonic and Induced Pluripotent Stem Cell Markers
• Epithelial Stem Cell Transcription Factors
• Hematopoietic Stem Cell Transcription Factors and Regulators
• Intracellular Signaling Molecules in Angiogenesis
• Pluripotent Stem Cell Transcription Factors
• Smad Family
• Smad Transcription Factors
• TGF-beta Family
• TGF-beta Superfamily Modulators
• Transcription Regulators in VSMC