Human Sonic Hedgehog/Shh N-Terminus Quantikine ELISA Kit Summary
Cell Culture Supernates, Serum, Heparin Plasma
|Intra-Assay Precision||Inter-Assay Precision|
The recovery of human Shh-N spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
|Sample Type||Average % Recovery||Range %|
|Cell Culture Media (n=4)||108||100-117|
|Heparin Plasma (n=4)||97||85-117|
Preparation and Storage
Background: Sonic Hedgehog/Shh
Shh (Sonic Hedgehog) is expressed in embryonic tissues that are critical for the patterning of the developing central nervous system, somite, and limb. It is also involved in whisker, hair, foregut, tooth, and bone development. Shh regulates neural and hematopoietic stem cell fate and is important for thymocyte differentiation and proliferation. In adult tissue Shh is associated with cancer development and tissue remodeling following injury. Palmitoylation and cholesterol addition of Shh contribute to its membrane tethering and assembly into multimers. Lipid modification and multimerization greatly increase Shh signaling potency. Shh can be released from the plasma membrane by the cooperative action of DISP1, SCUBE2, and TACE/ADAM17. Canonical signaling of Shh is mediated by a receptor complex that includes Patched (PTCH1, PTCH2) and Smoothened (SMO).
Citations for Human Sonic Hedgehog/Shh N-Terminus Quantikine ELISA Kit
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
Citations: Showing 1 - 2
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Hedgehog signaling contributes to bone cancer pain by regulating sensory neuron excitability in rats
Authors: S Liu, Y Lv, XX Wan, ZJ Song, YP Liu, S Miao, GL Wang, GJ Liu
Mol Pain, 2018;14(0):1744806918767.
Sample Types: Tissue Homogenates
High expression of Sonic hedgehog in allergic airway epithelia contributes to goblet cell metaplasia
Authors: C Xu, C Zou, M Hussain, W Shi, Y Shao, Z Jiang, X Wu, M Lu, J Wu, Q Xie, Y Ke, F Long, L Tang, X Wu
Mucosal Immunol, 2018;0(0):.
Sample Types: BALF
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