Human Stabilin-2 Antibody

Catalog # Availability Size / Price Qty
Detection of Stabilin‑2 in K562 Human Cell Line by Flow Cytometry.
1 Image
Product Details
Citations (2)
Supplemental Products

Human Stabilin-2 Antibody Summary

Species Reactivity
Detects human Stabilin-2 in direct ELISAs and Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant human Stabilin-1 is observed.
Polyclonal Sheep IgG
Antigen Affinity-purified
E. coli-derived recombinant human Stabilin-2
Accession # Q8WWQ8
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.


Recommended Concentration
Western Blot
0.1 µg/mL
Recombinant Human Stabilin‑2 (Catalog # 3645-S2)
Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
Intracellular Staining by Flow Cytometry
2.5 µg/106 cells
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Intracellular Staining by Flow Cytometry Detection of Stabilin-2 antibody in K562 Human Cell Line antibody by Flow Cytometry. View Larger

Detection of Stabilin‑2 in K562 Human Cell Line by Flow Cytometry. K562 human chronic myelogenous leukemia cell line was stained with Sheep Anti-Human Stabilin-2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3645, filled histogram) or isotype control antibody (Catalog # 5-001-A, open histogram), followed by NorthernLights™ 637-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # NL011).

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Preparation and Storage

Reconstitute at 0.2 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Size / Price
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Stabilin-2

Stabilin-2, also known as HARE (hyaluronan receptor for endocytosis) and FEEL-2 (fasciclin, EGF-like, laminin type EGF-like, and link domain containing scavenger receptor 2), is a type I transmembrane multi-domain protein that is the closest homolog of stabilin-1 (1, 2). It is a scavenger receptor that is expressed on sinusoidal endothelial cells of liver, spleen, and lymph node (1, 2). Its 2439 amino acid (aa) extracellular domain contains seven fasciclin domains, multiple EGF-like and laminin type EGF-like domains, and a link domain related to molecules of the TSG-6 superfamily (3). The 72 aa cytoplasmic tail of Stabilin-2 contains a motif that allows the AP2 classical cargo adaptor to direct cargo into clathrin-coated pits (4). As a recycling receptor, Stabilin-2 cycles from the membrane to clathrin-coated pits each 10‑15 minutes, with about two thirds of the protein found within the endocytic system at any one time (4). The link domain binds and mediates the systemic clearance of hyaluronan (HA) (2‑6). Within the link domain (aa 2198‑2295), human Stabilin-2 shares 86% and 89% aa identity with mouse and rat Stabilin-2, respectively. Total human HA is about 15 grams, of which about 5 grams are cleared each day (5). Stabilin-2 also mediates the endocytosis of chondroitin and chondroitin sulfate, advanced glycosylation end-product (AGE), collagen N-terminal propeptides and acetylated LDL (4‑7). Human Stabilin-2 mRNA encodes a 2251 aa, 315 kDa protein that produces an isoform of 190 kDa through proteolytic cleavage (2, 6). The 190 kDa form lacks some N-terminal fasciclin and EGF-like domains, but shows similar activities when compared with the 315 kDa form (2, 6).

  1. Politz, O. et al. (2002) Biochem. J. 362:155.
  2. Zhou, B. et al. (2003) Glycobiology 13:339.
  3. Blundell, C.D. et al. (2005) J. Biol. Chem. 280:18189.
  4. Hansen, B. et al. (2005) Exp. Cell Res. 303:160.
  5. Harris, E.N. et al. (2004) J. Biol. Chem. 279:36201.
  6. Harris, E.N. et al. (2007) J. Biol. Chem. 282:2785.
  7. Tamura, Y. et al. (2003) J. Biol. Chem. 278:12613.
Entrez Gene IDs
55576 (Human); 192188 (Mouse); 282580 (Rat)
Alternate Names
CD44-like precursor FELL; DKFZP434E0321; FAS1 EGF-like and X-link domain containing adhesion molecule-2; FAS1 EGF-like and X-link domain-containing adhesion molecule 2; fasciclin egf-like, laminin-type egf-like, and link domain-containing scavengerreceptor-2; Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavengerreceptor 2; FEEL2; FEEL-2; FELE-2; FELL; FELL-2; FEX2; HARE; HAREFELL2; hepatic hyaluronan clearance receptor; Hyaluronan receptor for endocytosis; hyaluronic acid receptor for endocytosis; STAB2; STAB-2; stabilin 2; Stabilin2; Stabilin-2

Product Datasheets

You must select a language.


Citations for Human Stabilin-2 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
Filter your results:

Filter by:

  1. Therapeutic correction of hemophilia A by transplantation of hPSC-derived liver sinusoidal endothelial cell progenitors
    Authors: BK Gage, S Merlin, C Olgasi, A Follenzi, GM Keller
    Cell Reports, 2022;39(1):110621.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  2. Red blood cell phosphatidylserine exposure is responsible for increased erythrocyte adhesion to endothelium in central retinal vein occlusion.
    Authors: Wautier MP, Heron E, Picot J, Colin Y, Hermine O, Wautier JL
    J. Thromb. Haemost., 2011;9(5):1049-55.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization


No product specific FAQs exist for this product, however you may

View all Antibody FAQs

Reviews for Human Stabilin-2 Antibody

There are currently no reviews for this product. Be the first to review Human Stabilin-2 Antibody and earn rewards!

Have you used Human Stabilin-2 Antibody?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review