Human TAPP1 Antibody
Human TAPP1 Antibody Summary
Accession # Q9HB21
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
TAPP1, gene name PLEKHA1 (pleckstrin homology family A, member 1) is a 70‑75 kDa cytoplasmic adaptor protein that is membrane-associated after binding of the phosphoinositide, PtdIns(3,4)P2. The 404 aa human TAPP1 shares 76% aa identity with mouse TAPP1. It is expressed most highly in skeletal muscle, spleen, lung, thymus and placenta. TAPP1 interacts with cytoskeletal syntrophins, colocalizing in membrane ruffles following PDGF treatment in transfected NIH‑3T3 cells. TAPP1 and the related TAPP2 appear to play a role in B and T cell activation.
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