Human TRAILR1/TNFRSF10A PE-conjugated Antibody
Human TRAILR1/TNFRSF10A PE-conjugated Antibody Summary
Ala24-Asn239
Accession # AAC51226
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Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of TRAIL R1/TNFRSF10A in HeLa Human Cell Line by Flow Cytometry. HeLa human cervical epithelial carcinoma cell line was stained with Mouse Anti-Human TRAIL R1/TNFRSF10A PE-conjugated Monoclonal Antibody (Catalog # FAB347P, filled histogram) or isotype control antibody (Catalog # IC002P, open histogram). View our protocol for Staining Membrane-associated Proteins.
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Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: TRAILR1/TNFRSF10A
Human TRAIL R1, also called DR4, is a type 1, TNF R family, membrane protein which is a receptor for TRAIL (APO2 ligand). In the TNF superfamily nomenclature, TRAIL RI is referred to as TNFRSF10A. TRAIL R1 cDNA encodes a 468 amino acid precursor protein containing extracellular cysteine-rich domains, a transmembrane domain and a cytoplasmic death domain. Among the TNF receptor family proteins, TRAIL R1 is most closely related to TRAIL R2/DR5, sharing 55% amino acid sequence identity. Binding of trimeric TRAIL to TRAIL R1 induces apoptosis. The induction of apoptosis likely requires oligomerization of the receptor. The human TRAIL R1/Fc chimera neutralizes the ability of TRAIL to induce apoptosis. Besides TRAIL R1, an additional TRAIL R2/DR5, which tranduces apoptosis signal, and two TRAIL decoy receptors, which antagonize TRAIL-induced apoptosis, have been reported.
Product Datasheets
Citations for Human TRAILR1/TNFRSF10A PE-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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TRAIL sensitivity of nasopharyngeal cancer cells involves redox dependent upregulation of TMTC2 and its interaction with membrane caspase-3
Authors: D Raman, P Tay, JL Hirpara, D Liu, S Pervaiz
Redox Biology, 2021;48(0):102193.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells
Authors: EB Jo, YS Lee, H Lee, JB Park, H Park, YL Choi, D Hong, SJ Kim
BMC Cancer, 2019;19(1):496.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
miR-494 Sensitizes Gastric Cancer Cells to TRAIL Treatment Through Downregulation of Survivin
Authors: S Xu, D Li, T Li, L Qiao, K Li, L Guo, Y Liu
Cell. Physiol. Biochem., 2018;51(5):2212-2223.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
TRAIL regulatory receptors constrain human hepatic stellate cell apoptosis
Authors: HD Singh, I Otano, K Rombouts, KP Singh, D Peppa, US Gill, K Böttcher, PTF Kennedy, J Oben, M Pinzani, H Walczak, G Fusai, WMC Rosenberg, MK Maini
Sci Rep, 2017;7(1):5514.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Kaempferol Sensitizes Human Ovarian Cancer Cells-OVCAR-3 and SKOV-3 to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)-Induced Apoptosis via JNK/ERK-CHOP Pathway and Up-Regulation of Death Receptors 4 and 5
Authors: Y Zhao, B Tian, Y Wang, H Ding
Med. Sci. Monit., 2017;23(0):5096-5105.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
The role of selected flavonols in tumor necrosis factor-related apoptosis-inducing ligand receptor-1 (TRAIL-R1) expression on activated RAW 264.7 macrophages.
Authors: Warat M, Sadowski T, Szliszka E, Krol W, Czuba Z
Molecules, 2015;20(1):900-12.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Potential application of temozolomide in mesenchymal stem cell-based TRAIL gene therapy against malignant glioma.
Authors: Kim, Seong Mu, Woo, Ji Sun, Jeong, Chang Hy, Ryu, Chung He, Jang, Jae-Deog, Jeun, Sin-Soo
Stem Cells Transl Med, 2014;3(2):172-82.
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Chrysin, apigenin and acacetin inhibit tumor necrosis factor-related apoptosis-inducing ligand receptor-1 (TRAIL-R1) on activated RAW264.7 macrophages.
Authors: Warat M, Szliszka E, Korzonek-Szlacheta I, Krol W, Czuba Z
Int J Mol Sci, 2014;15(7):11510-22.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
TRAIL-engineered bone marrow-derived mesenchymal stem cells: TRAIL expression and cytotoxic effects on C6 glioma cells.
Authors: Tang X, Lu J, Tu H, Huang K, Fu R, Cao G, Huang M, Cheng L, Dai L, Zhang L
Anticancer Res, 2014;34(2):729-34.
Species: Rat
Sample Types: Whole Cells
Applications: Flow Cytometry -
Smad7 protein induces interferon regulatory factor 1-dependent transcriptional activation of caspase 8 to restore tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis.
Authors: Hong S, Kim H, Kim J, Ha H, Kim Y, Bae E, Kim T, Lee K, Kim S
J Biol Chem, 2013;288(5):3560-70.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Translational phase I trial of vorinostat (suberoylanilide hydroxamic acid) combined with cytarabine and etoposide in patients with relapsed, refractory, or high-risk acute myeloid leukemia.
Authors: Gojo I, Tan M, Fang H, Sadowska M, Lapidus R, Baer M, Carrier F, Beumer J, Anyang B, Srivastava R, Espinoza-Delgado I, Ross D
Clin Cancer Res, 2013;19(7):1838-51.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Azadirone, a limonoid tetranortriterpene, induces death receptors and sensitizes human cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through a p53 protein-independent mechanism: evidence for the role of the ROS-ERK-CHOP-death receptor pathway.
Authors: Gupta, Subash C, Francis, Sajin K, Nair, Mangalam, Mo, Yin-Yuan, Aggarwal, Bharat B
J Biol Chem, 2013;288(45):32343-56.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
TRAIL(+) human plasmacytoid dendritic cells kill tumor cells in vitro: mechanisms of imiquimod- and IFN-alpha-mediated antitumor reactivity.
Authors: Kalb ML, Glaser A, Stary G, Koszik F, Stingl G
J. Immunol., 2012;188(4):1583-91.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Drozitumab, a human antibody to death receptor 5, has potent antitumor activity against rhabdomyosarcoma with the expression of caspase-8 predictive of response.
Authors: Kang Z, Chen J, Yu Y, Li B, Sun S, Zhang B, Cao L
Clin Cancer Res, 2011;17(10):3181-92.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
The dietary flavonol fisetin enhances the apoptosis-inducing potential of TRAIL in prostate cancer cells.
Authors: Szliszka E, Helewski KJ, Mizgala E, Krol W
Int. J. Oncol., 2011;39(4):771-9.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Epigenetic silencing of death receptor 4 mediates tumor necrosis factor-related apoptosis-inducing ligand resistance in gliomas.
Authors: Elias A, Siegelin MD, Steinmuller A, von Deimling A, Lass U, Korn B, Mueller W
Clin. Cancer Res., 2009;15(17):5457-65.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Tumor necrosis factor-related apoptosis-inducing ligand promotes migration of human bone marrow multipotent stromal cells.
Authors: Secchiero P, Melloni E, Corallini F, Beltrami AP, Alviano F, Milani D, D'Aurizio F, di Iasio MG, Cesselli D, Bagnara GP, Zauli G
Stem Cells, 2008;26(11):2955-63.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Gene therapy using TRAIL-secreting human umbilical cord blood-derived mesenchymal stem cells against intracranial glioma.
Authors: Kim SM, Lim JY, Park SI, Jeong CH, Oh JH, Jeong M, Oh W, Park SH, Sung YC, Jeun SS
Cancer Res., 2008;68(23):9614-23.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
TRAIL recombinant adenovirus triggers robust apoptosis in multidrug-resistant HL-60/Vinc cells preferentially through death receptor DR5.
Authors: Wu CH, Kao CH, Safa AR
Hum. Gene Ther., 2008;19(7):731-43.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell-mediated liver damage.
Authors: Dunn C, Brunetto M, Reynolds G, Christophides T, Kennedy PT, Lampertico P, Das A, Lopes AR, Borrow P, Williams K, Humphreys E, Afford S, Adams DH, Bertoletti A, Maini MK
J. Exp. Med., 2007;204(3):667-80.
Species: Human
Sample Types: Serum
Applications: Flow Cytometry
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