ICI 182,780

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ICI 182,780 | CAS No. 129453-61-8 | Estrogen and Related Receptor Antagonists
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Description: Estrogen receptor antagonist
Alternative Names: Fulvestrant

Chemical Name: 7α,17β-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol

Purity: ≥99%

Product Details
Citations (284)

Biological Activity

ICI 182,780 is a high affinity estrogen receptor antagonist (IC50 = 0.29 nM), devoid of any partial agonism both in vitro and in vivo. ICI 182,780 is a high affinity agonist at the membrane estrogen receptor GPER. ICI 182,780 inhibits MCF-7 human breast cancer cell growth in vitro and shows antitumor activity in mice models. ICI 182,780 penetrates the blood-brain-barrier and has neuronal functional effects in vivo.

Technical Data

Soluble to 50 mM in ethanol and to 100 mM in DMSO
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for ICI 182,780

The citations listed below are publications that use Tocris products. Selected citations for ICI 182,780 include:

284 Citations: Showing 1 - 10

  1. Pancreatic Ins content regulation by the estrogen receptor ER alpha.
    Authors: Alonso-Magdalena Et al.
    PLoS One  ;3:e2069
  2. Glutamine Metabolism Drives Growth in Advanced Hormone Receptor Positive Breast Cancer.
    Authors: Demas Et al.
    Front Oncol  2019;9:686
  3. Chronic cadmium exposure decreases the dependency of MCF7 breast cancer cells on ERα.
    Authors: Bloomfield and Louie
    Sci Rep  2019;9:12135
  4. TAX mechanically deactivates hepatic stellate cells via the G protein-coupled estrogen receptor.
    Authors: Cortes Et al.
    Oncogene  2019;38:2910
  5. Data on UPLC/MS method validation for the biodegradation of pharmaceuticals and intermediates by a fungal consortium and on T47DK-Bluc reporter gene assay to assess the reduction of their estrogenic activity.
    Authors: Kasonga Et al.
    Data Brief  2019;25:104336
  6. GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment.
    Authors: Cortes Et al.
    EMBO Rep  2019;20
  7. TAX mechanically reprograms the tumor microenvironment via HIF-1A and reduces cancer cell survival.
    Authors: Cortes Et al.
    EMBO Rep  2019;20
  8. F-Spondin Is the Signal by Which 2-Methoxyestradiol Induces Apoptosis in the Endometrial Cancer Cell Line Ishikawa.
    Authors: Rincó n-Rodriguez Et al.
    Int J Mol Sci  2019;20
  9. Estrogen therapy induces an unfolded protein response to drive cell death in ER+ breast cancer.
    Authors: Hosford Et al.
    Mol Oncol  2019;13:1778
  10. Role for the transcriptional activator ZRF1 in early metastatic events in breast cancer progression and endocrine resistance.
    Authors: Kaymak Et al.
    Oncotarget  2018;9:28666
  11. Brain Aromatase Modulates Serotonergic Neuron by Regulating Serotonin Levels in Zebrafish Embryos and Larvae.
    Authors: Ulhaq and Kishida
    Front Endocrinol (Lausanne)  2018;9:230
  12. A transcriptomics model of estrogen action in the ovine fetal hypothalamus: evidence for estrogenic effects of ICI 182,780.
    Authors: Rabaglino Et al.
    Physiol Rep  2018;6:e13871
  13. 17β-Estradiol and ICI182,780 Differentially Regulate STAT5 Isoforms in Female Mammary Epithelium, With Distinct Outcomes.
    Authors: Jallow Et al.
    J Endocr Soc  2018;2:293
  14. The impact of 27-hydroxycholesterol on endometrial cancer proliferation.
    Authors: Gibson Et al.
    Endocr Relat Cancer  2018;25:381
  15. Key regulators of lipid metabolism drive endocrine resistance in invasive lobular breast cancer.
    Authors: Du Et al.
    Breast Cancer Res  2018;20:106
  16. Upregulation of IRS1 Enhances IGF1 Response in Y537S and D538G ESR1 Mutant Breast Cancer Cells.
    Authors: Li Et al.
    Endocrinology  2018;159:285
  17. Estrogenicity of essential oils is not required to relieve symptoms of urogenital atrophy in breast cancer survivors.
    Authors: Simões Et al.
    Ther Adv Med Oncol  2018;10:1758835918766180
  18. Estrogen enhances mismatch repair by induction of MLH1 expression via estrogen receptor-β.
    Authors: Lu Et al.
    Oncotarget  2017;8:38767
  19. Structural and molecular mechanisms of cytokine-mediated endocrine resistance in human breast cancer cells.
    Authors: Stender
    Mol Cell  2017;65(6):1122
  20. E2 via estrogen receptor beta influences ROS levels through the transcriptional regulation of SIRT3 in human seminoma TCam-2 cells.
    Authors: Panza Et al.
    Tumour Biol  2017;39:1010428317701640
  21. Role of inducible nitric oxide synthase in endothelium-independent relaxation to RLX in rat aorta.
    Authors: Wong Et al.
    Br J Pharmacol  2017;174:718
  22. OE Suppresses TLR4-triggered Apoptosis of Decidual Stromal Cells and Drives an Anti-inflammatory TH2 Shift by Activating SGK1.
    Authors: Lou Et al.
    Int J Biol Sci  2017;13:434
  23. Differential and directional estrogenic signaling pathways induced by enterolignans and their precursors.
    Authors: Zhu
    PLoS One  2017;12(2):e0171390
  24. Identification of Differential ER-Alpha Versus ER-Beta Mediated Activation of eNOS in Ovine Uterine Artery Endothelial Cells.
    Authors: Pastore Et al.
    Biol Reprod  2016;94:139
  25. Multiple direct and indirect mechanisms drive estrogen-induced tumor growth in high grade serous ovarian cancers.
    Authors: Ciucci Et al.
    Oncotarget  2016;7:8155
  26. Low expression of estrogen receptor β in T lymphocytes and high serum levels of anti-estrogen receptor α antibodies impact disease activity in female patients with systemic lupus erythematosus.
    Authors: Maselli Et al.
    Front Vet Sci  2016;7:3
  27. Antiestrogen resistant cell lines expressing estrogen receptor α mutations upregulate the unfolded protein response and are killed by BHPI
    Authors: Mao Et al.
    Scientific Reports  2016;6:34753
  28. Estrogen protects against DA neuron toxicity in primary mesencephalic cultures through an indirect P13K/Akt mediated astrocyte pathway.
    Authors: Bains and Roberts
    Neurosci Lett  2016;610:79
  29. NCOA3 coactivator is a transcriptional target of XBP1 and regulates PERK-eIF2α-ATF4 signalling in breast cancer.
    Authors: Gupta Et al.
    Oncogene  2016;35:5860
  30. Estrogenic compounds reduce influenza A virus replication in primary human nasal epithelial cells derived from female, but not male, donors.
    Authors: Peretz Et al.
    Am J Physiol Lung Cell Mol Physiol  2016;310:L415
  31. Progesterone induces progesterone receptor gene (PGR) expression via rapid activation of protein kinase pathways required for cooperative estrogen receptor alpha (ER) and progesterone receptor (PR) genomic action at ER/PR target genes.
    Authors: Diep Et al.
    Steroids  2016;114:48
  32. Endogenous 17β-OE is required for activity-dependent long-term potentiation in the striatum: interaction with the DArgic system.
    Authors: Tozzi Et al.
    Front Cell Neurosci  2015;9:192
  33. Differential effects of estrogen and estrogen receptor antagonist, ICI 182 780, on the expression of calbindin-D9k in rat pituitary prolactinoma GH3 cells.
    Authors: Wang Et al.
    Cancer Cell Int  2015;7:8498
  34. A cluster of noncoding RNAs activates the ESR1 locus during breast cancer adaptation.
    Authors: Tomita Et al.
    Nat Commun  2015;6:6966
  35. A short report: PAMM, a novel antioxidant protein, induced by oxidative stress.
    Authors: Xu Et al.
    Redox Biol  2015;6:446
  36. Altered radiation responses of breast cancer cells resistant to hormonal therapy.
    Authors: Luzhna Et al.
    Mol Cell Biol  2015;6:1678
  37. Methoxychlor and its metabolite HPTE inhibit cAMP production and expression of estrogen receptors α and β in the rat granulosa cell in vitro.
    Authors: Harvey Et al.
    Reprod Toxicol  2015;51:72
  38. Nodes-and-connections RNAi knockdown screening: identification of a signaling molecule network involved in fulves. action and breast cancer prognosis.
    Authors: Miyoshi Et al.
    Biol Sex Differ  2015;4:e172
  39. Differential expression of upstream stimulatory factor (USF) 2 variants in eutopic endometria from women with endometriosis: OE regulation.
    Authors: Castro Et al.
    Biol Res  2015;48:56
  40. New cell culture model for aromatase inhibitor-resistant breast cancer shows sensitivity to fulves. treatment and cross-resistance between letr. and exeme.
    Authors: Hole Et al.
    BMC Cancer  2015;46:1481
  41. NF-κB signaling is required for XBP1 (unspliced and spliced)-mediated effects on antiestrogen responsiveness and cell fate decisions in breast cancer.
    Authors: Hu Et al.
    Oncogenesis  2015;35:379
  42. PHLDA1 expression is controlled by an estrogen receptor-NFκB-miR-181 regulatory loop and is essential for formation of ER+ mammospheres.
    Authors: Kastrati Et al.
    Oncogene  2015;34:2309
  43. The Effects of Steroid Implant and Dietary Soybean Hulls on Estrogenic Activity of Sera of Steers Grazing Toxic Endophyte-Infected Tall Fescue Pasture.
    Authors: Shappell Et al.
    Cancer Lett  2015;2:30
  44. Estrogenic and anti-estrogenic activity of off-the-shelf hair and skin care products.
    Authors: Myers Et al.
    BMC Cancer  2015;25:271
  45. Effects of estrogen on growth and smooth muscle differentiation of vascular wall-resident CD34(+) stem/progenitor cells.
    Authors: Wu Et al.
    Atherosclerosis  2015;240:453
  46. Evaluation of the pharmacological activities of RAD1901, a selective estrogen receptor degrader.
    Authors: Wardell Et al.
    Endocr Relat Cancer  2015;22:713
  47. Aurora kinase B is important for antiestrogen resistant cell growth and a potential biomarker for tamox. resistant breast cancer.
    Authors: Larsen Et al.
    Aging Cell  2015;15:239
  48. Antihormonal agents as a strategy to improve the effect of chemo-radiation in cervical cancer: in vitro and in vivo study.
    Authors: Segovia-Mendoza Et al.
    J Biol Chem  2015;15:21
  49. Opposite effects of two estrogen receptors on tau phosphorylation through disparate effects on the miR-218/PTPA pathway.
    Authors: Xiong Et al.
    Breast Cancer Res Treat  2015;14:867
  50. Estrogen mediated expression of nucleophosmin 1 in human endometrial carcinoma clinical stages through estrogen receptor-α signaling.
    Authors: Zhou Et al.
    Endocrinology  2015;14:540
  51. The PI3K/mTOR dual inhibitor P7170 demonstrates potent activity against endocrine-sensitive and endocrine-resistant ER+ breast cancer.
    Authors: Bean Et al.
    Oncotarget  2015;149:69
  52. Estrogen promotes luteolysis by redistributing prostaglandin F2α receptors within primate luteal cells.
    Authors: Kim Et al.
    Reproduction  2015;149:453
  53. Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity.
    Authors: Simões Et al.
    Cell Cycle  2015;12:1968
  54. Effects of Atrazine on Estrogen Receptor α- and G Protein-Coupled Receptor 30-Mediated Signaling and Proliferation in Cancer Cells and Cancer-Associated Fibroblasts.
    Authors: Albanito Et al.
    Environ Health Perspect  2015;123:493
  55. Antiapoptotic factor humanin is expressed in normal and tumoral pituitary cells and protects them from TNF-α-induced apoptosis.
    Authors: Gottardo Et al.
    PLoS One  2014;9:e111548
  56. Comprehensive analysis of prostaglandin metabolic enzyme expression during pregnancy and the characterization of AKR1B1 as a prostaglandin F synthase at the maternal-conceptus interface in pigs.
    Authors: Seo Et al.
    Breast Cancer Res  2014;90:99
  57. Diaryl and heteroaryl sulfides: synthesis via sulfenyl chlorides and evaluation as selective anti-breast-cancer agents.
    Authors: Yonova Et al.
    J Org Chem  2014;79:1947
  58. Effects of Estetrol on Migration and Invasion in T47-D Breast Cancer Cells through the Actin Cytoskeleton.
    Authors: Giretti Et al.
    Front Endocrinol (Lausanne)  2014;5:80
  59. Functional analysis of MKP-1 and MKP-2 in breast cancer tamox. sensitivity.
    Authors: Haagenson Et al.
    Oncotarget  2014;5:1101
  60. Inhibition of c-Src blocks oestrogen-induced apoptosis and restores oestrogen-stimulated growth in long-term oestrogen-deprived breast cancer cells.
    Authors: Fan Et al.
    Eur J Cancer  2014;50:457
  61. A molecular model for the mechanism of acquired tamox. resistance in breast cancer.
    Authors: Fan Et al.
    Eur J Cancer  2014;50:2866
  62. Anti-tumor efficacy of fulves. in estrogen receptor positive gastric cancer.
    Authors: Yi Et al.
    Sci Rep  2014;4:7592
  63. β-D-glucan inhibits endocrine-resistant breast cancer cell proliferation and alters gene expression.
    Authors: Jafaar Et al.
    Int J Oncol  2014;44:1365
  64. Oestrogen upregulates the sarcoplasmic reticulum Ca(2+) ATPase pump in coronary arteries.
    Authors: Hill and Muldrew
    Clin Exp Pharmacol Physiol  2014;41:430
  65. Egr1 protein acts downstream of estrogen-leukemia inhibitory factor (LIF)-STAT3 pathway and plays a role during implantation through targeting Wnt4.
    Authors: Liang Et al.
    J Biol Chem  2014;289:23534
  66. Activation of a Gq-coupled membrane estrogen receptor rapidly attenuates α2-adrenoceptor-induced antinociception via an ERK I/II-dependent, non-genomic mechanism in the female rat.
    Authors: Nag and Mokha
    Am J Physiol Regul Integr Comp Physiol  2014;267:122
  67. Suppression of autophagic activation in the mouse uterus by estrogen and progesterone.
    Authors: Choi Et al.
    Cell Rep  2014;221:39
  68. Hormonal regulation of epithelial organization in a three-dimensional breast tissue culture model.
    Authors: Speroni Et al.
    PLoS One  2014;20:42
  69. In vitro chronic administration of ERbeta selective ligands and prostate cancer cell growth: hypotheses on the selective role of 3beta-adiol in AR-positive RV1 cells.
    Authors: Colciago Et al.
    Biomed Res Int  2014;2014:801473
  70. Selective inhibition of RET mediated cell proliferation in vitro by the kinase inhibitor SPP86.
    Authors: Alao Et al.
    BMC Cancer  2014;14:853
  71. Breast tumor specific mutation in GATA3 affects physiological mechanisms regulating transcription factor turnover.
    Authors: Adomas Et al.
    BMC Cancer  2014;14:278
  72. OE increases cAMP in the oviductal secretory cells through a nongenomic mechanism.
    Authors: Oróstica Et al.
    Reproduction  2014;148:285
  73. Estrogen receptor-α signaling and localization regulates autophagy and unfolded protein response activation in ER+ breast cancer.
    Authors: Cook and Clarke
    Steroids  2014;1
  74. GDNF-RET signaling in ER-positive breast cancers is a key determinant of response and resistance to aromatase inhibitors.
    Authors: Morandi Et al.
    Cancer Res  2013;73:3783
  75. Gender differences in brain susceptibility to oxidative stress are mediated by levels of paraoxonase-2 expression.
    Authors: Giordano Et al.
    Free Radic Biol Med  2013;58:98
  76. Expression of the aryl hydrocarbon receptor is not required for the proliferation, migration, invasion, or estrogen-dependent tumorigenesis of MCF-7 breast cancer cells.
    Authors: Spink Et al.
    Mol Carcinog  2013;52:544
  77. Retinoic acid receptor alpha is associated with tamox. resistance in breast cancer.
    Authors: Johansson Et al.
    Nat Commun  2013;4:2175
  78. Induction of hepatic multidrug resistance-associated protein 3 by ethynylOE is independent of cholestasis and mediated by estrogen receptor.
    Authors: Ruiz Et al.
    Proc Natl Acad Sci U S A  2013;41:275
  79. The membrane estrogen receptor ligand STX rapidly enhances GABAergic signaling in NPY/AgRP neurons: role in mediating the anorexigenic effects of 17β-OE.
    Authors: Smith Et al.
    Am J Physiol Endocrinol Metab  2013;305:E632
  80. ERβ-dependent effects on uterine endothelial cells are cell specific and mediated via Sp1.
    Authors: Greaves Et al.
    Hum Reprod  2013;28:2490
  81. The effect of estrogen compounds on human embryoid bodies.
    Authors: Kim Et al.
    Proc Natl Acad Sci U S A  2013;20:661
  82. OOE signalling through the Akt-mTORC1-S6K1.
    Authors: Varea Et al.
    Biochim Biophys Acta  2013;1833:1052
  83. Amphiregulin mediates progesterone-induced mammary ductal development during puberty.
    Authors: Aupperlee Et al.
    J Neurosci  2013;15:R44
  84. OE promotes the development of a fibrotic phenotype and is increased in the serum of patients with systemic sclerosis.
    Authors: Aida-Yasuoka Et al.
    J Neurosci  2013;15:R10
  85. Fulvestrant regulates epidermal growth factor (EGF) family ligands to activate EGF receptor (EGFR) signaling in breast cancer cells.
    Authors: Zhang Et al.
    Environ Health Perspect  2013;139:351
  86. Differential action of monohydroxylated polycyclic aromatic hydrocarbons with estrogen receptors α and β.
    Authors: Sievers Et al.
    Proc Natl Acad Sci U S A  2013;132:359
  87. Endocrine disruptors fludioxonil and fenhexamid stimulate miR-21 expression in breast cancer cells.
    Authors: Teng Et al.
    Toxicol Sci  2013;131:71
  88. 17β-OE-induced interaction of ERα with NPPA regulates gene expression in cardiomyocytes.
    Authors: Mahmoodzadeh Et al.
    Cardiovasc Res  2012;96:411
  89. Modulation of ovine SBD-1 expression by 17beta-OE in ovine oviduct epithelial cells.
    Authors: Wen Et al.
    BMC Vet Res  2012;8:143
  90. Bisphenol A inhibits follicle growth and induces atresia in cultured mouse antral follicles independently of the genomic estrogenic pathway.
    Authors: Peretz Et al.
    Biol Reprod  2012;87:63
  91. p130Cas over-expression impairs mammary branching morphogenesis in response to estrogen and EGF.
    Authors: Leal Et al.
    PLoS One  2012;7:e49817
  92. The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer.
    Authors: Vinnedge Et al.
    Neuroscience  2012;7:e46985
  93. Screening estrogenic activities of chemicals or mixtures in vivo using transgenic (cyp19a1b-GFP) zebrafish embryos.
    Authors: Brion Et al.
    PLoS One  2012;7:e36069
  94. Insotropic effect of the non-steroidal compound STX in pancreatic β-cells.
    Authors: Ropero Et al.
    PLoS One  2012;7:e34650
  95. Estrogen prevents oxidative damage to the mitochondria in Friedreich's ataxia skin fibroblasts.
    Authors: Richardson Et al.
    Endocrinology  2012;7:e34600
  96. Estrogen receptor β dependent attenuation of cytokine-induced cyclooxygenase-2 by androgens in human brain vascular smooth muscle cells and rat mesenteric arteries.
    Authors: Zuloaga Et al.
    Exp Neurol  2012;77:835
  97. Glucose-regulated protein 78 controls cross-talk between apoptosis and autophagy to determine antiestrogen responsiveness.
    Authors: Cook Et al.
    Int J Mol Sci  2012;72:3337
  98. Pre-B cell to macrophage transdifferentiation without significant promoter DNA methylation changes.
    Authors: Rodriguez-Ubreva Et al.
    Nucleic Acids Res  2012;40:1954
  99. Estrogen receptor is activated by korean red ginseng in vitro but not in vivo.
    Authors: Shim and Lee
    J Ginseng Res  2012;36:169
  100. Estrogen-responsive nitroso-proteome in uterine artery endothelial cells: role of endothelial nitric oxide synthase and estrogen receptor-β.
    Authors: Zhang Et al.
    J Cell Physiol  2012;227:146
  101. Activation of Estrogen Receptor by Bavachin from Psoralea corylifolia.
    Authors: Park Et al.
    Proc Natl Acad Sci U S A  2012;20:183
  102. MGMT inhibition restores ERα functional sensitivity to antiestrogen therapy.
    Authors: Bobustuc Et al.
    Mol Med  2012;18:913
  103. OE increases cell growth in human astrocytoma cell lines through ERα activation and its interaction with SRC-1 and SRC-3 coactivators.
    Authors: González-Arenas Et al.
    Biochim Biophys Acta  2012;1823:379
  104. Effects of gonadal hormones on the peripheral cannabinoid receptor 1 (CB1R) system under a myositis condition in rats.
    Authors: Niu Et al.
    J Cereb Blood Flow Metab  2012;153:2283
  105. OE directly attenuates sodium currents and depolarizing afterpotentials in isolated gonadotropin-releasing hormone neurons.
    Authors: Wang and Kuehl-Kovarik
    Brain Res  2012;1436:81
  106. Genistein prevents hyperglycemia-induced monocyte adhesion to human aortic endothelial cells through preservation of the cAMP signaling pathway and ameliorates vascular inflammation in obese diabetic mice.
    Authors: Babu Et al.
    J Nutr  2012;142:724
  107. Estrogen receptor β activation is antinociceptive in a model of visceral pain in the rat.
    Authors: Cao Et al.
    J Pain  2012;13:685
  108. Inhibition of p38-MAPK alters SRC coactivation and estrogen receptor phosphorylation.
    Authors: Antoon Et al.
    Cancer Biol Ther  2012;13:1026
  109. Antiestrogenic activity of flavonoid phytochemicals mediated via the c-Jun N-terminal protein kinase pathway. Cell-type specific regulation of estrogen receptor alpha.
    Authors: Collins-Burow Et al.
    J Steroid Biochem Mol Biol  2012;132:186
  110. Estrogen-like activity of aqueous extract from Agrimonia pilosa Ledeb. in MCF-7 cells.
    Authors: Lee Et al.
    Endocrinology  2012;12:260
  111. Inhibition of XO or NOX attenuates diethylstilbestrol-induced endothelial nitric oxide deficiency without affecting its effects on LNCaP cell invasion and apoptosis.
    Authors: Youn Et al.
    Clin Sci (Lond)  2012;123:509
  112. Estrogen receptor β (ERβ) produces autophagy and necroptosis in human seminoma cell line through the binding of the Sp1 on the phosphatase and tensin homolog deleted from chromosome 10 (PTEN) promoter gene.
    Authors: Guido Et al.
    Int J Clin Exp Pathol  2012;11:2911
  113. Generation of stable reporter breast cancer cell lines for the identification of ER subtype selective ligands.
    Authors: Shanle Et al.
    Biochem Pharmacol  2011;82:1940
  114. 17β-OE enhances breast cancer cell motility and invasion via extra-nuclear activation of actin-binding protein ezrin.
    Authors: Zheng Et al.
    PLoS One  2011;6:e22439
  115. mTOR controls ovarian follicle growth by regulating granulosa cell proliferation.
    Authors: Yu Et al.
    PLoS One  2011;6:e21415
  116. Daidzein prevents the increase in CD4+CD28null T cells and B lymphopoesis in ovariectomized mice: a key mechanism for anti-osteoclastogenic effect.
    Authors: Tyagi Et al.
    PLoS One  2011;6:e21216
  117. The cholesterol metabolite 25-hydroxycholesterol activates estrogen receptor α-mediated signaling in cancer cells and in cardiomyocytes.
    Authors: Lappano Et al.
    PLoS One  2011;6:e16631
  118. The effect of 17β-OE on cholesterol content in human macrophages is influenced by the lipoprotein milieu.
    Authors: Corcoran Et al.
    Clin Cancer Res  2011;47:109
  119. Complete estrogen receptor blocker ICI182,780 promotes the proliferation of vascular smooth muscle cells.
    Authors: He Et al.
    Acta Biochim Biophys Sin (Shanghai)  2011;43:118
  120. Spinal synthesis of estrogen and concomitant signaling by membrane estrogen receptors regulate spinal κ- and μ-opioid receptor heterodimerization and female-specific spinal mor. antinociception.
    Authors: Liu Et al.
    J Neurosci  2011;31:11836
  121. Selective mutations in estrogen receptor alpha D-domain alters nuclear translocation and non-estrogen response element gene regulatory mechanisms.
    Authors: Burns Et al.
    J Biol Chem  2011;286:12640
  122. Tamoxifen increases nuclear respiratory factor 1 transcription by activating estrogen receptor beta and AP-1 recruitment to adjacent promoter binding sites.
    Authors: Ivanova Et al.
    FASEB J  2011;25:1402
  123. The liver receptor homolog-1 (LRH-1) is expressed in human islets and protects {β}-cells against stress-induced apoptosis.
    Authors: Baquié Et al.
    FEMS Immunol Med Microbiol  2011;20:2823
  124. JNK suppression is essential for 17β-OE inhibits prostaglandin E2-Induced uPA and MMP-9 expressions and cell migration in human LoVo colon cancer cells.
    Authors: Hsu Et al.
    J Vet Sci  2011;18:61
  125. Therapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancer.
    Authors: Thangavel Et al.
    Endocr Relat Cancer  2011;18:333
  126. Estrogen protection in Friedreich's ataxia skin fibroblasts.
    Authors: Richardson Et al.
    Endocrinology  2011;152:2742
  127. Expression and regulation of Enpp2 in rat uterus during the estrous cycle.
    Authors: Ahn Et al.
    Toxicol Sci  2011;12:379
  128. 17beta-OE inhibits matrix metalloproteinase-2 transcription via MAP kinase in fibroblasts.
    Authors: Mahmoodzadeh Et al.
    Cardiovasc Res  2010;85:719
  129. Developmental exposures of male rats to soy isoflavones impact Leydig cell differentiation.
    Authors: Sherrill Et al.
    Biol Reprod  2010;83:488
  130. Interdependence of platelet-derived growth factor and estrogen-signaling pathways in inducing neonatal rat testicular gonocytes proliferation.
    Authors: Thuillier Et al.
    Biol Reprod  2010;82:825
  131. Hepatocyte growth factor system in the mouse uterus: variation across the estrous cycle and regulation by 17-β-OE and progesterone.
    Authors: Zhang
    Clin Cancer Res  2010;82:1037
  132. BRD7, a subunit of SWI/SNF complexes, binds directly to BRCA1 and regulates BRCA1-dependent transcription.
    Authors: Harte Et al.
    Cancer Res  2010;70:2538
  133. Estrogen suppresses MLK3-mediated apoptosis sensitivity in ER+ breast cancer cells.
    Authors: Rangasamy Et al.
    Cancer Res  2010;70:1731
  134. Extranuclear estrogen receptors mediate the neuroprotective effects of estrogen in the rat hippocampus.
    Authors: Yang Et al.
    PLoS One  2010;5:e9851
  135. Cell cycle and anti-estrogen effects synergize to regulate cell proliferation and ER target gene expression.
    Authors: Dalvai and Bystricky
    PLoS One  2010;5:e11011
  136. Estrogen receptor-mediated enhancement of venous relaxation in female rat: implications in sex-related differences in varicose veins.
    Authors: Raffetto Et al.
    J Vasc Surg  2010;51:972
  137. OE selectively stimulates endothelial prostacyclin production through estrogen receptor-{alpha}.
    Authors: Sobrino Et al.
    J Mol Endocrinol  2010;44:237
  138. Estrogen-receptor-mediated protection of cerebral endothelial cell viability and mitochondrial function after ischemic insult in vitro.
    Authors: Guo Et al.
    PLoS One  2010;30:545
  139. c-Jun activation is required for 4-hydroxytamoxifen-induced cell death in breast cancer cells.
    Authors: Madeo Et al.
    Oncogene  2010;29:978
  140. Estrogen receptor α (ERα) mediates 17β-OE (E2)-activated expression of HBO1.
    Authors: Wang Et al.
    Proc Natl Acad Sci U S A  2010;29:140
  141. 5-HT(1A), SST(1), and SST(2) receptors mediate inhibitory postsynaptic potentials in the submucous plexus of the guinea pig ileum.
    Authors: Foong Et al.
    Receptors Clin Investig  2010;298:G384
  142. Bisphenol A and OE are equipotent in antagonizing cisplatin-induced cytotoxicity in breast cancer cells.
    Authors: LaPensee Et al.
    Cancer Res  2010;290:167
  143. Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of Ins-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-i
    Authors: Sunters Et al.
    J Biol Chem  2010;285:8743
  144. Androgen receptor-dependent transactivation of growth arrest-specific gene 6 mediates inhibitory effects of testost. on vascular calcification.
    Authors: Son Et al.
    J Biol Chem  2010;285:7537
  145. Proinflammatory cytokines enhance estrogen-dependent expression of the multidrug transporter gene ABCG2 through estrogen receptor and NF{kappa}B cooperativity at adjacent response elements.
    Authors: Pradhan Et al.
    J Biol Chem  2010;285:31100
  146. Down-regulation of PROS1 gene expression by 17beta-OE via estrogen receptor alpha (ERalpha)-Sp1 interaction recruiting receptor-interacting protein 140 and the corepressor-HDAC3 complex.
    Authors: Suzuki Et al.
    J Biol Chem  2010;285:13444
  147. Gender-specific reduction in contraction is associated with increased estrogen receptor expression in single vascular smooth muscle cells of female rat.
    Authors: Ma Et al.
    Cell Physiol Biochem  2010;26:457
  148. Estrogen receptor-alpha promotes breast cancer cell motility and invasion via focal adhesion kinase and N-WASP.
    Authors: Sanchez Et al.
    Mol Endocrinol  2010;24:2114
  149. Unexpected hormonal activity of a catechol equine estrogen metabolite reveals reversible glutathione conjugation.
    Authors: Peng Et al.
    Chem Res Toxicol  2010;23:1374
  150. Roles of 17β-OE involve regulation of reelin expression and synaptogenesis in the dentate gyrus.
    Authors: Bender Et al.
    Cereb Cortex  2010;20:2985
  151. Proliferation of human mammary cancer cells exposed to 27-hydroxycholesterol.
    Authors: Cruz Et al.
    J Expo Sci Environ Epidemiol  2010;1:531
  152. B7-H1-dependent sex-related differences in tumor immunity and immunotherapy responses.
    Authors: Lin Et al.
    J Immunol  2010;185:2747
  153. OE suppresses NF-kappa B activation through coordinated regulation of let-7a and miR-125b in primary human macrophages.
    Authors: Murphy Et al.
    J Immunol  2010;184:5029
  154. Prolactin and oestrogen synergistically regulate gene expression and proliferation of breast cancer cells.
    Authors: Rasmussen Et al.
    Endocr Relat Cancer  2010;17:809
  155. Progesterone increases systemic and local uterine proportions of CD4+CD25+ Treg cells during midterm pregnancy in mice.
    Authors: Mao Et al.
    Endocrinology  2010;151:5477
  156. Antiestrogenic effects of the novel sphingosine kinase-2 inhibitor ABC294640.
    Authors: Antoon Et al.
    Endocrinology  2010;151:5124
  157. Estrogen stimulates proliferation and differentiation of neural stem/progenitor cells through different signal transduction pathways.
    Authors: Okada Et al.
    Am J Physiol Heart Circ Physiol  2010;11:4114
  158. Bisphenol A impairs the double-strand break repair machinery in the germline and causes chromosome abnormalities.
    Authors: Allard and Colaiácovo
    Proc Natl Acad Sci U S A  2010;107:20405
  159. Autocrine regulation of cell proliferation by estrogen receptor-alpha in estrogen receptor-alpha-positive breast cancer cell lines.
    Authors: Tan Et al.
    BMC Cancer  2009;9:31
  160. Blockade of estrogen action upregulates estrogen receptor-alpha mRNA in the fetal brain.
    Authors: Schaub and Wood
    Neonatology  2009;96:115
  161. Effects of 17beta-oOE on rat detrusor smooth muscle contractility.
    Authors: Valeri Et al.
    Exp Physiol  2009;94:834
  162. The estrogen receptor alpha pathway induces oncogenic Wip1 phosphatase gene expression.
    Authors: Han Et al.
    Mol Cancer Res  2009;7:713
  163. Tamoxifen inhibits TRPV6 activity via estrogen receptor-independent pathways in TRPV6-expressing MCF-7 breast cancer cells.
    Authors: Bolanz Et al.
    Mol Cancer Res  2009;7:2000
  164. Characterization of a novel small molecule subtype specific estrogen-related receptor alpha antagonist in MCF-7 breast cancer cells.
    Authors: Chisamore Et al.
    PLoS One  2009;4:e5624
  165. The expression of Wnt4 is regulated by estrogen via an estrogen receptor alpha-dependent pathway in rat pituitary GH-producing cells.
    Authors: Miyakoshi Et al.
    Acta Histochem Cytochem  2009;42:205
  166. OE stimulates Akt, AMP-activated protein kinase (AMPK) and TBC1D1/4, but not glucose uptake in rat soleus.
    Authors: Rogers Et al.
    Biochem Biophys Res Commun  2009;382:646
  167. The oxysterol receptor LXR inhibits proliferation of human breast cancer cells.
    Authors: Vedin Et al.
    Cancer Res  2009;30:575
  168. CRK7 modifies the MAPK pathway and influences the response to endocrine therapy.
    Authors: Iorns Et al.
    Carcinogenesis  2009;30:1696
  169. OE-induced estrogen receptor-α trafficking.
    Authors: Bondar Et al.
    Mol Cell Endocrinol  2009;29:15323
  170. Estrogen attenuates ischemic oxidative damage via an estrogen receptor alpha-mediated inhibition of NADPH oxidase activation.
    Authors: Zhang Et al.
    J Neurosci  2009;29:13823
  171. Cytoskeletal changes underlie estrogen's acute effects on synaptic transmission and plasticity.
    Authors: Kramár Et al.
    Hum Mol Genet  2009;29:12982
  172. K+-dependent Na+/Ca2+ exchanger 3 is involved in renal active calcium transport and is differentially expressed in the mouse kidney.
    Authors: Lee Et al.
    Am J Physiol Renal Physiol  2009;297:F371
  173. A novel mechanism of natural vitamin E tocotrienol activity: involvement of ERbeta signal transduction.
    Authors: Comitato Et al.
    Am J Physiol Endocrinol Metab  2009;297:E427
  174. Mutational analysis of progesterone receptor functional domains in stable cell lines delineates sets of genes regulated by different mechanisms.
    Authors: Quiles Et al.
    Mol Endocrinol  2009;23:809
  175. Cell death mechanisms in GT1-7 GnRH cells exposed to polychlorinated biphenyls PCB74, PCB118, and PCB153.
    Authors: Dickerson Et al.
    Toxicol Appl Pharmacol  2009;237:237
  176. Mechanism of the salutary effects of estrogen on kupffer cell phagocytic capacity following trauma-hemorrhage: pivotal role of Akt activation.
    Authors: Hsieh Et al.
    J Immunol  2009;182:4406
  177. Differential actions of estrogen and SERMs in regulation of the actin cytoskeleton of endometrial cells.
    Authors: Flamini Et al.
    Mol Hum Reprod  2009;15:675
  178. Soy phytoestrogens are neuroprotective against stroke-like injury in vitro.
    Authors: Schreihofer and Redmond
    Neuroscience  2009;158:602
  179. Protopanaxadiol and protopanaxatriol bind to glucocorticoid and oestrogen receptors in endothelial cells.
    Authors: Leung Et al.
    Br J Pharmacol  2009;156:626
  180. 17Beta-OE at low concentrations acts through distinct pathways in normal versus benign prostatic hyperplasia-derived prostate stromal cells.
    Authors: Park Et al.
    Endocrinology  2009;150:4594
  181. Identification of the potent phytoestrogen glycinol in elicited soybean (Glycine max).
    Authors: Boue Et al.
    Endocrinology  2009;150:2446
  182. Blockade of estrogen receptor signaling inhibits growth and migration of medulloblastoma.
    Authors: Belcher Et al.
    Endocrinology  2009;150:1112
  183. Isoflavone genistein protects human vascular endothelial cells against tumor necrosis factor-alpha-induced apoptosis through the p38beta mitogen-activated protein kinase.
    Authors: Si
    Apoptosis  2009;14:66
  184. Hes-6, an inhibitor of Hes-1, is regulated by 17β-OE and promotes breast cancer cell proliferation.
    Authors: Hartman Et al.
    Arthritis Res Ther  2009;11:R79
  185. Characterization of housekeeping genes in zebrafish: male-female differences and effects of tissue type, developmental stage and chemical treatment.
    Authors: McCurley and Callard
    BMC Mol Biol  2008;9:102
  186. Estrogen determines sex differences in airway responsiveness after allergen exposure.
    Authors: Matsubara Et al.
    Reprod Sci  2008;38:501
  187. Estrogen prevents intestinal inflammation after trauma-hemorrhage via downregulation of angiotensin II and angiotensin II subtype I receptor.
    Authors: Chen Et al.
    J Mol Endocrinol  2008;295:G1131
  188. Genomic deletion of estrogen receptors ERalpha and ERbeta does not alter estrogen-mediated inhibition of Ca2+ influx and contraction in murine cardiomyocytes.
    Authors: Ullrich Et al.
    Am J Physiol Heart Circ Physiol  2008;294:H2421
  189. Tyrosine phosphorylation of the nuclear receptor coactivator AIB1/SRC-3 is enhanced by Abl kinase and is required for its activity in cancer cells.
    Authors: Oh Et al.
    Mol Cell Biol  2008;28:6580
  190. Progesterone induction of the 11beta-hydroxysteroid dehydrogenase type 2 promoter in breast cancer cells involves coordinated recruitment of STAT5A and progesterone receptor to a distal enhancer and polymerase tracking.
    Authors: Subtil-Rodríguez Et al.
    Mol Cell Biol  2008;28:3830
  191. Hormonal regulation of BCRP expression in human placental BeWo cells.
    Authors: Wang Et al.
    Pharm Res  2008;25:444
  192. Differential regulation of the inducible nitric oxide synthase gene by estrogen receptors 1 and 2.
    Authors: Tsutsumi Et al.
    Tissue Eng Part C Methods  2008;199:267
  193. The expression and ovarian steroid regulation of endometrial micro-RNAs.
    Authors: Toloubeydokhti Et al.
    J Exp Clin Cancer Res  2008;15:993
  194. Roles of estrogen receptor alpha and beta in modulating urothelial cell proliferation.
    Authors: Teng Et al.
    Endocr Relat Cancer  2008;15:351
  195. Effects of OE and progesterone on the proinflammatory cytokine production by mononuclear cells from patients with chronic hepatitis C.
    Authors: Yuan Et al.
    World J Gastroenterol  2008;14:2200
  196. Estrogen-enhanced gene expression of lipoprotein lipase in heart is antagonized by progesterone.
    Authors: Liu Et al.
    Endocrinology  2008;149:711
  197. The novel estrogen receptor, G protein-coupled receptor 30, mediates the proliferative effects induced by 17β-OE on mouse spermatogonial GC-1 cell line.
    Authors: Sirianni Et al.
    Int J Oncol  2008;149:5043
  198. The nutritional flavanone naringenin triggers antiestrogenic effects by regulating estrogen receptor alpha-palmitoylation.
    Authors: Galluzzo Et al.
    Endocrinology  2008;149:2567
  199. Identification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancer.
    Authors: Iorns Et al.
    Cancer Cell  2008;13:91
  200. Genistein, a soy phytoestrogen, upregulates the expression of human endothelial nitric oxide synthase and lowers blood pressure in spontaneously hypertensive rats.
    Authors: Si and Liu
    J Nutr  2008;138:297
  201. Differential expression of microRNAs in myometrium and leiomyomas and regulation by ovarian steroids.
    Authors: Pan Et al.
    J Biol Chem  2008;12:227
  202. G-protein-coupled receptor 30 and estrogen receptor-alpha are involved in the proliferative effects induced by atrazine in ovarian cancer cells.
    Authors: Albanito Et al.
    Environ Health Perspect  2008;116:1648
  203. Estrogen receptor independent neurotoxic mechanism of bisphenol A, an environmental estrogen.
    Authors: Lee Et al.
    J Vet Sci  2007;8:27
  204. Blockade of estrogen receptors decreases CNS and pituitary prostaglandin synthase expression in fetal sheep.
    Authors: Schaub Et al.
    FASEB J  2007;87:121
  205. Genistein chemoprevention of prostate cancer in TRAMP mice.
    Authors: Wang Et al.
    J Carcinog  2007;6:3
  206. Definition of functionally important mechanistic differences among selective estrogen receptor down-regulators.
    Authors: Wittmann Et al.
    Cancer Res  2007;67:9549
  207. G protein-coupled receptor 30 (GPR30) mediates gene expression changes and growth response to 17beta-OE and selective GPR30 ligand G-1 in ovarian cancer cells.
    Authors: Albanito Et al.
    Cancer Res  2007;67:1859
  208. NM23-H2, an estrogen receptor β-associated protein, shows diminished expression with progression of atherosclerosis.
    Authors: Rayner Et al.
    Reprod Sci  2007;292:R743
  209. Regulation of GREB1 transcription by estrogen receptor α through a multipartite enhancer spread over 20 kb of upstream flanking sequences.
    Authors: Deschênes Et al.
    BMC Complement Altern Med  2007;282:17335
  210. The silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) corepressor is required for full estrogen receptor alpha transcriptional activity.
    Authors: Peterson Et al.
    Mol Cell Biol  2007;27:5933
  211. Estrogen regulates Bcl-w and Bim expression: role in protection against beta-amyloid peptide-induced neuronal death.
    Authors: Yao Et al.
    J Neurosci  2007;27:1422
  212. 17β-OE utilizes the estrogen receptor to regulate CD16 expression in monocytes.
    Authors: Kramer Et al.
    Stroke  2007;279:16
  213. Kruppel-like factor 9 is a negative regulator of ligand-dependent estrogen receptor alpha signaling in Ishikawa endometrial adenocarcinoma cells.
    Authors: Velarde Et al.
    Mol Endocrinol  2007;21:2988
  214. Modulation of estrogen receptor α protein level and survival function by DBC-1.
    Authors: Trauernicht Et al.
    Br J Pharmacol  2007;21:1526
  215. Neuroprotection by tamox. in focal cerebral ischemia is not mediated by an agonist action at estrogen receptors but is associated with antioxidant activity.
    Authors: Zhang Et al.
    Exp Neurol  2007;204:819
  216. Neuroprotection by estrogen against MPP+-induced DA neuron death is mediated by ERα in primary cultures of mouse mesencephalon.
    Authors: Bains Et al.
    Biol Reprod  2007;204:767
  217. Resveratrol inhibits expression and binding activity of the monocyte chemotactic protein-1 receptor, CCR2, on THP-1 monocytes.
    Authors: Cullen Et al.
    Atherosclerosis  2007;195:e125
  218. Activation of estrogen receptor-mediated gene transcription by the equine estrogen metabolite, 4-methoxyequilenin, in human breast cancer cells.
    Authors: Chang Et al.
    Endocrinology  2007;148:4793
  219. Exposure to phytoestrogens in the perinatal period affects androgen secretion by testicular Leydig cells in the adult rat.
    Authors: Akingbemi Et al.
    Endocrinology  2007;148:4475
  220. MAPK signaling is critical to OE protection of CA1 neurons in global ischemia.
    Authors: Jover-Mengual Et al.
    Endocrinology  2007;148:1131
  221. Reversal of the estrogen receptor negative phenotype in breast cancer and restoration of antiestrogen response.
    Authors: Bayliss Et al.
    Clin Cancer Res  2007;13:7029
  222. OE-17beta regulates mouse uterine epithelial cell proliferation through Ins-like growth factor 1 signaling.
    Authors: Zhu and Pollard
    Proc Natl Acad Sci U S A  2007;104:15847
  223. Additive growth inhibitory effects of ibandr. and antiestrogens in estrogen receptor-positive breast cancer cell lines.
    Authors: Journé Et al.
    Cancer Res  2006;8:R2
  224. Farnesyl-transferase inhibitor R115,777 enhances tamox. inhibition of MCF-7 cell growth through estrogen receptor dependent and independent pathways.
    Authors: Dalenc Et al.
    Breast Cancer Res  2006;7:R1159
  225. Royal jelly stimulates bone formation: physiologic and nutrigenomic studies with mice and cell lines.
    Authors: Narita Et al.
    Biosci Biotechnol Biochem  2006;70:2508
  226. 17beta-OE, genistein, and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the g protein-coupled receptor GPR30.
    Authors: Vivacqua Et al.
    Mol Pharmacol  2006;70:1414
  227. Estrogens, selective estrogen receptor modulators, and a selective estrogen receptor down-regulator inhibit endothelial production of tissue factor pathway inhibitor 1.
    Authors: Dahm Et al.
    BMC Cardiovasc Disord  2006;6:40
  228. Cyclin D1 is necessary for tamoxifen-induced cell cycle progression in human breast cancer cells.
    Authors: Kilker and Planas-Silva
    Breast Cancer Res  2006;66:11478
  229. Efficient intracellular multiplication of Legionella pneumophila in human monocytes requires functional host cell L-type calcium channels.
    Authors: Wieland Et al.
    Am J Physiol Gastrointest Liver Physiol  2006;47:296
  230. 17β-OE inhibits subarachnoid hemorrhage-induced inducible nitric oxide synthase gene expression by interfering with the nuclear factor κ B transactivation.
    Authors: Shih Et al.
    Proc Natl Acad Sci U S A  2006;37:3025
  231. Convergent transcriptional profiles induced by endogenous estrogen and distinct xenoestrogens in breast cancer cells.
    Authors: Buterin Et al.
    Carcinogenesis  2006;27:1567
  232. Antiestrogens and the formation of DNA damage in rats: a comparison.
    Authors: Kim Et al.
    Infect Immun  2006;19:852
  233. The hop phytoestrogen, 8-prenylnaringenin, reverses the ovariectomy-induced rise in skin temperature in an animal model of menopausal hot flushes.
    Authors: Bowe Et al.
    J Endocrinol  2006;191:399
  234. Tamoxifen dilates porcine coronary arteries: roles for nitric oxide and ouabain-sensitive mechanisms.
    Authors: Leung Et al.
    Br J Pharmacol  2006;149:703
  235. Activation of Ins-like growth factor I receptor-mediated pathway by ginsenoside Rg1.
    Authors: Chen Et al.
    Br J Pharmacol  2006;147:542
  236. Biological role of estrogen receptor β in salivary gland adenocarcinoma cells.
    Authors: Ohshiro Et al.
    Exp Ther Med  2006;12:5994
  237. The estrogenic effect of bisphenol A disrupts pancreatic β-cell function in vivo and induces Ins resistance.
    Authors: Alonso-Magdalena Et al.
    Am J Physiol Gastrointest Liver Physiol  2006;114:106
  238. Disruption of estrogen receptor DNA-binding domain and related intramolecular communication restores tamox. sensitivity in resistant breast cancer.
    Authors: Wang Et al.
    BMC Immunol  2006;10:487
  239. A model of acquired autoresistance to a potent ErbB2 tyrosine kinase inhibitor and a therapeutic strategy to prevent its onset in breast cancer.
    Authors: Xia Et al.
    Br J Cancer  2006;103:7795
  240. An inherent role of microtubule network in the action of nuclear receptor.
    Authors: Manavathi Et al.
    J Endocrinol  2006;103:15981
  241. Estrogen receptor signaling protects against immune suppression by UV radiation exposure.
    Authors: Widyarini Et al.
    Neuroendocrinology  2006;103:12837
  242. Estrogen receptor alpha pathway is involved in the regulation of Calbindin-D9k in the uterus of immature rats.
    Authors: Lee Et al.
    Toxicol Sci  2005;84:270
  243. Deregulation of cell proliferation by polycyclic aromatic hydrocarbons in human breast carcinoma MCF-7 cells reflects both genotoxic and nongenotoxic events.
    Authors: Pl?sková Et al.
    Toxicol Sci  2005;83:246
  244. Membrane estrogen receptor-alpha levels predict estrogen-induced ERK1/2 activation in MCF-7 cells.
    Authors: Zivadinovic and Watson
    Breast Cancer Res  2005;7:R130
  245. Effects of OE on lipopolysaccharide and Pam3Cys stimulation of CCL20/macrophage inflammatory protein 3 α and tumor necrosis factor α production by uterine epithelial cells in culture.
    Authors: Crane-Godreau and Wira
    Breast Cancer Res Treat  2005;73:4231
  246. Gonadal steroids differentially modulate neurotoxicity of HIV and cocaine: testost. and ICI 182,780 sensitive mechanism.
    Authors: Kendall Et al.
    BMC Neurosci  2005;6:40
  247. Estren promotes androgen phenotypes in primary lymphoid organs and submandibular glands.
    Authors: Islander Et al.
    Reprod Nutr Dev  2005;6:16
  248. Estrogen increases mitochondrial efficiency and reduces oxidative stress in cerebral blood vessels.
    Authors: Stirone Et al.
    Mol Pharmacol  2005;68:959
  249. Regulation of endogenous gene expression in human non-small cell lung cancer cells by estrogen receptor ligands.
    Authors: Hershberger Et al.
    Cancer Cell  2005;65:1598
  250. The effects of dietary phytoestrogens on aromatase activity in human endometrial stromal cells.
    Authors: Edmunds Et al.
    Environ Health Perspect  2005;45:709
  251. Soy isoflavones improve endothelial function in spontaneously hypertensive rats in an estrogen-independent manner: role of nitric-oxide synthase, superoxide, and cyclooxygenase metabolites.
    Authors: Vera Et al.
    J Pharmacol Exp Ther  2005;314:1300
  252. Formation of an IKKalpha-dependent transcription complex is required for estrogen receptor-mediated gene activation.
    Authors: Park Et al.
    Mol Cell  2005;18:71
  253. Palmitoylation-dependent estrogen receptor alpha membrane localization: regulation by 17beta-OE.
    Authors: Acconcia Et al.
    Mol Biol Cell  2005;16:231
  254. Progesterone antagonizes the permissive action of OE on tumor necrosis factor-α-induced apoptosis of anterior pituitary cells.
    Authors: Candolfi Et al.
    Proc Natl Acad Sci U S A  2005;146:736
  255. Firing pattern and rapid modulation of activity by estrogen in primate luteinizing hormone releasing hormone-1 neurons.
    Authors: Abe and Terasawa
    Endocrinology  2005;146:4312
  256. Estrogen modulates endothelial and neuronal nitric oxide synthase expression via an estrogen receptor beta-dependent mechanism in hypothalamic slice cultures.
    Authors: Gingerich and Krukoff
    Endocrinology  2005;146:2933
  257. Estrogenic effects of two derivatives of icariin on human breast cancer MCF-7 cells.
    Authors: Ye and Lou
    Phytomedicine  2005;12:735
  258. Identification of target genes in breast cancer cells directly regulated by the SRC-3/AIB1 coactivator.
    Authors: Labhart Et al.
    Proc Natl Acad Sci U S A  2005;102:1339
  259. Steroid-free medium discloses oestrogenic effects of the bisphosphonate clodr. on breast cancer cells.
    Authors: Journe Et al.
    Breast Cancer Res  2004;91:1703
  260. Tamoxifen and the Rafoxifene analog LY117018: their effects on arachidonic acid release from cells in culture and on prostaglandin I2 production by rat liver cells.
    Authors: Levine
    Proc Natl Acad Sci U S A  2004;4:49
  261. Age-related reduction in estrogen receptor-mediated mechanisms of vascular relaxation in female spontaneously hypertensive rats.
    Authors: Wynne Et al.
    Hypertension  2004;43:405
  262. Wnt/β-catenin and estrogen signaling converge in vivo.
    Authors: Kouzmenko Et al.
    Am J Respir Cell Mol Biol  2004;279:40255
  263. The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-OE and phytoestrogens in breast cancer cells.
    Authors: Maggiolini Et al.
    J Biol Chem  2004;279:27008
  264. Morphological effects of estrogen on cholinergic neurons in vitro involves activation of extracellular signal-regulated kinases.
    Authors: Dominguez Et al.
    Carcinogenesis  2004;24:982
  265. HES-1 inhibits 17β-OE and heregulin-β1-mediated upregulation of E2F-1.
    Authors: Hartman Et al.
    J Cell Mol Med  2004;23:8826
  266. Nuclear Ins receptor substrate 1 interacts with estrogen receptor alpha at ERE promoters.
    Authors: Morelli Et al.
    Oncogene  2004;23:7517
  267. Estrogen receptor beta isoforms exhibit differences in ligand-activated transcriptional activity in an estrogen response element sequence-dependent manner.
    Authors: Ramsey Et al.
    Endocrinology  2004;145:149
  268. Xenoestrogen-induced ERK-1 and ERK-2 activation via multiple membrane-initiated signaling pathways.
    Authors: Bulayeva and Watson
    Environ Health Perspect  2004;112:1481
  269. Human epidermal growth factor receptor 2 status modulates subcellular localization of and interaction with estrogen receptor α in breast cancer cells.
    Authors: Yang Et al.
    Oncogene  2004;10:3621
  270. Regulation of PDGF production and ERK activation by estrogen is associated with TSC2 gene expression.
    Authors: Finlay Et al.
    Am J Physiol Cell Physiol  2003;285:C409
  271. The effects of estrogen, its antagonist ICI 182, 780, and IF.-tau on the expression of estrogen receptors and integrin alphaV beta 3 on cycle day 16 in bovine endometrium.
    Authors: Kimmins Et al.
    Reprod Biol Endocrinol  2003;1:38
  272. Inhibition of prolactin (PRL)-induced proliferative signals in breast cancer cells by a molecular mimic of phosphorylated PRL, S179D-PRL.
    Authors: Schroeder Et al.
    Biomol Ther (Seoul)  2003;144:5300
  273. Environmental estrogens alter early development in Xenopus laevis.
    Authors: Bevan Et al.
    J Endocrinol  2003;111:488
  274. Involvement of bone morphogenetic protein 4 (BMP-4) in pituitary prolactinoma pathogenesis through a Smad/estrogen receptor crosstalk.
    Authors: Paez-Pereda Et al.
    BMC Cancer  2003;100:1034
  275. Testosterone attenuates expression of vascular cell adhesion molecule-1 by conversion to OE by aromatase in endothelial cells: implications in atherosclerosis.
    Authors: Mukherjee Et al.
    Mol Endocrinol  2002;99:4055
  276. OE reduces F2α-isoprostane production in cultured human endothelial cells.
    Authors: Hermenegildo Et al.
    Biol Reprod  2002;283:H2644
  277. Receptor-mediated ethinylOE-induced oxidative DNA damage in rat testicular cells.
    Authors: Wellejus and Loft
    Proc Natl Acad Sci U S A  2002;16:195
  278. 17-β-oOE-induced vasorelaxation in vitro is mediated by eNOS through hsp90 and akt/pkb dependent mechanism.
    Authors: Bucci Et al.
    Drug Metab Dispos  2002;135:1695
  279. DDT and its metabolites alter gene expression in human uterine cell lines through estrogen receptor-independent mechanisms.
    Authors: Frigo Et al.
    Environ Health Perspect  2002;110:1239
  280. Estrogen alters thresholds for B cell apoptosis and activation.
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    J Clin Invest  2002;109:1625
  281. The antioxidant neuroprotective effects of estrogens and phenolic compounds are independent from their estrogenic properties.
    Authors: Moosmann and Behl
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  282. Estrogen receptor (ER) modulators each induce distinct conformational changes in ER α and ER β.
    Authors: Paige Et al.
    J Biomed Sci  1999;96:3999
  283. OE induces the calcium-dependent translocation of endothelial nitric oxide synthase.
    Authors: Goetz Et al.
    J Neurosci  1999;96:2788
  284. High level expression of differentially localized BAG-1 isoforms in some oestrogen receptor-positive human breast cancers.
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