Chemical Name: 1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol
Biological ActivitySustains self-renewal and pluripotency of mouse embryonic stem cells (ESCs) in vitro. Stimulates proliferation at a steady rate (observed in serum-free media supplemented with 10 μM over a 30 day period). Also supports human PSC maintenance in combiantions with Wnt3a. DYRK inhibitor
The technical data provided above is for guidance only.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Indole derivatives sustain embryonic stem cell self-renewal in long-term culture.
Miyabayashi et al.
Controlling destiny through chemistry: small-molecule regulators of cell fate.
Firestone and Chen
ACS Chem.Biol., 2009;5:15
Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion.
Hasegawa et al.
Stem Cells Transl.Med., 2012;1:18
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