Chemical Name: Heptanedioic acid-1-(2-cyclopentylidenehydrazide)
Biological Activity Cell-permeable inducer of definitive endoderm formation in mouse and human embryonic stem cells (ESCs) (EC50 = 223 nM for induction of Sox17 expression in ESCs). Reported to activate TGF-β signaling and downstream Smad2 phosphorylation; upregulates Nodal expression. Promotes pancreatic progenitor cell formation in vitro, and gut tube formation in vivo.
Soluble to 20 mM in water and to 100 mM in DMSO
Store at +4°C
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