Chemical Name: Heptanedioic acid-1-(2-cyclopentylidenehydrazide)
Biological ActivityCell-permeable inducer of definitive endoderm formation in mouse and human embryonic stem cells (ESCs) (EC50 = 223 nM for induction of Sox17 expression in ESCs). Reported to activate TGF-β signaling and downstream Smad2 phosphorylation; upregulates Nodal expression. Promotes pancreatic progenitor cell formation in vitro, and gut tube formation in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells.
Borowiak M, Maehr R, Chen S, Chen AE, Tang W, Fox JL, Schreiber SL, Melton DA
Cell Stem Cell, 2009;4(4):348-58.
Using small molecules to great effect in stem cell differentiation.
Cell Stem Cell, 2009;4:373
Stimulation of AVNA/Nodal signaling is insufficient to induce definitive endoderm formation of cord blood-derived unrestricted somatic stem cells.
Filby et al.
Stem Cell Res.Ther., 2011;2:16
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