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IFN-gamma [Unconjugated]

Catalog #: LUM485
28 Citations Datasheet / COA / SDS
Newer Version Available: LXSAMSM
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Discontinued Product

LUM485 has been discontinued and is replaced by LXSAMSM.

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Citations (28)
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IFN-gamma [Unconjugated] Summary

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Preparation and Storage

Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: IFN-gamma

IFN-gamma (Interferon-gamma) is the prototype proinflammatory cytokine and is produced by a variety of immune cells under inflammatory conditions, notably by T cells and NK cells. It plays a key role in host defense by promoting the development and activation of Th1 cells, chemoattraction and activation of monocytes and macrophages, upregulation of antigen presentation molecules, and immunoglobulin class switching in B cells. It also exhibits antiviral, antiproliferative, and apoptotic effects. In addition, IFN-gamma functions as an anti-inflammatory mediator by promoting the development of regulatory T cells and inhibiting Th17 cell differentiation. IFN-gamma dimers signal through a receptor complex of two IFN-gamma R1 and two IFN-gamma R2 subunits.

Long Name
Interferon gamma
Entrez Gene IDs
3458 (Human); 15978 (Mouse); 25712 (Rat); 396991 (Porcine); 281237 (Bovine); 403801 (Canine); 493965 (Feline)
Alternate Names
IFG; IFI; IFNG; IFNgamma; IFN-gamma

Citations for IFN-gamma [Unconjugated]

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

28 Citations: Showing 1 - 10
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  1. Glucopyranosyl Lipid Adjuvant (GLA), a Synthetic TLR4 agonist, promotes potent systemic and mucosal responses to intranasal immunization with HIVgp140.
    Authors: Arias, Mauricio, Van Roey, Griet A, Tregoning, John S, Moutaftsi, Magdalin, Coler, Rhea N, Windish, Hillarie, Reed, Steven G, Carter, Darrick, Shattock, Robin J
    PLoS ONE, 2012-07-19;7(7):e41144.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  2. Tissue factor promotes activation of coagulation and inflammation in a mouse model of sickle cell disease.
    Authors: Chantrathammachart P, Mackman N, Sparkenbaugh E
    Blood, 2012-06-01;120(3):636-46.
    Species: Mouse
    Sample Types: Plasma
  3. Bridging the gap between preclinical and clinical microbicide trials: blind evaluation of candidate gels in murine models of efficacy and safety.
    Authors: Segarra TJ, Fakioglu E, Cheshenko N
    PLoS ONE, 2011-11-11;6(11):e27675.
    Species: Mouse
    Sample Types: Vaginal Lavage Fluid
  4. Hematopoietic Fas deficiency does not affect experimental atherosclerotic lesion formation despite inducing a proatherogenic state.
    Authors: de Claro RA, Zhu X, Tang J, Morgan-Stevenson V, Schwartz BR, Iwata A, Liles WC, Raines EW, Harlan JM
    Am. J. Pathol., 2011-05-06;178(6):2931-7.
    Species: Mouse
    Sample Types: Plasma
  5. Hematopoietic cell-restricted deletion of CD36 reduces high-fat diet-induced macrophage infiltration and improves insulin signaling in adipose tissue.
    Authors: Nicholls HT, Kowalski G, Kennedy DJ
    Diabetes, 2011-03-04;60(4):1100-10.
    Species: Mouse
    Sample Types: Plasma
  6. The biological activity of FasL in human and mouse lungs is determined by the structure of its stalk region.
    Authors: Herrero R, Kajikawa O, Matute-Bello G
    J. Clin. Invest., 2011-03-01;121(3):1174-90.
    Species: Mouse
    Sample Types: Tissue Homogenates
  7. Granzyme A- and B-cluster deficiency delays acute lung injury in pneumovirus-infected mice.
    Authors: Bem RA, van Woensel JB, Lutter R, Domachowske JB, Medema JP, Rosenberg HF, Bos AP
    J. Immunol., 2009-12-16;184(2):931-8.
    Species: Mouse
    Sample Types: BALF
  8. Tissue inhibitor of metalloproteinases 3 regulates resolution of inflammation following acute lung injury.
    Authors: Gill SE, Huizar I, Bench EM
    Am. J. Pathol., 2009-12-11;176(1):64-73.
    Species: Mouse
    Sample Types: BALF
  9. Effects of age on the synergistic interactions between lipopolysaccharide and mechanical ventilation in mice.
    Authors: Smith LS, Gharib SA, Frevert CW, Martin TR
    Am. J. Respir. Cell Mol. Biol., 2009-11-09;43(4):475-86.
    Species: Mouse
    Sample Types: Tissue Homogenates
  10. 3',5'-Cyclic diguanylic acid elicits mucosal immunity against bacterial infection.
    Authors: Yan H, KuoLee R, Tram K, Qiu H, Zhang J, Patel GB, Chen W
    Biochem. Biophys. Res. Commun., 2009-07-16;387(3):581-4.
    Species: Mouse
    Sample Types: BALF
  11. Multipotent adult progenitor cells can suppress graft-versus-host disease via prostaglandin E2 synthesis and only if localized to sites of allopriming.
    Authors: Highfill SL, Kelly RM, O'Shaughnessy MJ, Zhou Q, Xia L, Panoskaltsis-Mortari A, Taylor PA, Tolar J, Blazar BR
    Blood, 2009-05-20;114(3):693-701.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  12. Inactivation of the adenosine A2A receptor protects apolipoprotein E-deficient mice from atherosclerosis.
    Authors: Wang H, Zhang W, Zhu C, Bucher C, Blazar BR, Zhang C, Chen JF, Linden J, Wu C, Huo Y
    Arterioscler. Thromb. Vasc. Biol., 2009-04-30;29(7):1046-52.
    Species: Mouse
    Sample Types: Plasma
  13. Mechanical ventilation enhances lung inflammation and caspase activity in a model of mouse pneumovirus infection.
    Authors: Bem RA, van Woensel JB, Bos AP, Koski A, Farnand AW, Domachowske JB, Rosenberg HF, Martin TR, Matute-Bello G
    Am. J. Physiol. Lung Cell Mol. Physiol., 2008-11-07;296(1):L46-56.
    Species: Mouse
    Sample Types: BALF
  14. Mitogenic effect contributes to increased virulence of Streptococcus suis sequence type 7 to cause streptococcal toxic shock-like syndrome.
    Authors: Zheng H, Ye C, Segura M, Gottschalk M, Xu J
    Clin. Exp. Immunol., 2008-09-01;153(3):385-91.
    Species: Mouse
    Sample Types: Serum
  15. Depletion of resident alveolar macrophages does not prevent Fas-mediated lung injury in mice.
    Authors: Bem RA, Farnand AW, Wong V, Koski A, Rosenfeld ME, Van Rooijen N, Frevert CW, Martin TR, Matute-Bello G
    Am. J. Physiol. Lung Cell Mol. Physiol., 2008-06-13;295(2):L314-25.
    Species: Mouse
    Sample Types: Tissue Homogenates
  16. Differential effects of donor T-cell cytokines on outcome with continuous bortezomib administration after allogeneic bone marrow transplantation.
    Authors: Sun K, Li M, Sayers TJ, Welniak LA, Murphy WJ
    Blood, 2008-06-06;112(4):1522-9.
    Species: Mouse
    Sample Types: Serum
  17. Matrix metalloproteinase-7 (matrilysin) controls neutrophil egress by generating chemokine gradients.
    Authors: Swee M, Wilson CL, Wang Y, McGuire JK, Parks WC
    J. Leukoc. Biol., 2008-03-11;83(6):1404-12.
    Species: Mouse
    Sample Types: Tissue Homogenates
  18. Altered inflammatory responses in TLR5-deficient mice infected with Legionella pneumophila.
    Authors: Hawn TR, Berrington WR, Smith IA, Uematsu S, Akira S, Aderem A, Smith KD, Skerrett SJ
    J. Immunol., 2007-11-15;179(10):6981-7.
    Species: Mouse
    Sample Types: Tissue Homogenates
  19. Potent induction of TNF-alpha during interaction of immune effectors with oral tumors as a potential mechanism for the loss of NK cell viability and function.
    Authors: Romero-Reyes M, Head C, Cacalano NA, Jewett A
    Apoptosis, 2007-11-01;12(11):2063-75.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  20. Neutrophils play an important role in host resistance to respiratory infection with Acinetobacter baumannii in mice.
    Authors: van Faassen H, KuoLee R, Harris G, Zhao X, Conlan JW, Chen W
    Infect. Immun., 2007-10-01;75(12):5597-608.
    Species: Mouse
    Sample Types: Serum
  21. A new murine model for bronchiolitis obliterans post-bone marrow transplant.
    Authors: Panoskaltsis-Mortari A, Tram KV, Price AP, Wendt CH, Blazar BR
    Am. J. Respir. Crit. Care Med., 2007-06-15;176(7):713-23.
    Species: Mouse
    Sample Types: Serum
  22. Essential role of MMP-12 in Fas-induced lung fibrosis.
    Authors: Matute-Bello G, Wurfel MM, Lee JS, Park DR, Frevert CW, Madtes DK, Shapiro SD, Martin TR
    Am. J. Respir. Cell Mol. Biol., 2007-04-19;37(2):210-21.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  23. Deficiency of P-selectin or P-selectin glycoprotein ligand-1 leads to accelerated development of glomerulonephritis and increased expression of CC chemokine ligand 2 in lupus-prone mice.
    Authors: He X, Schoeb TR, Panoskaltsis-Mortari A, Zinn KR, Kesterson RA, Zhang J, Samuel S, Hicks MJ, Hickey MJ, Bullard DC
    J. Immunol., 2006-12-15;177(12):8748-56.
    Species: Mouse
    Sample Types: Tissue Homogenates
  24. Identification and characterization of noncalcemic, tissue-selective, nonsecosteroidal vitamin D receptor modulators.
    Authors: Ma Y, Khalifa B, Yee YK, Lu J, Memezawa A, Savkur RS, Yamamoto Y, Chintalacharuvu SR, Yamaoka K, Stayrook KR, Bramlett KS, Zeng QQ, Chandrasekhar S, Yu XP, Linebarger JH, Iturria SJ, Burris TP, Kato S, Chin WW, Nagpal S
    J. Clin. Invest., 2006-03-09;116(4):892-904.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  25. Resistance to experimental autoimmune encephalomyelitis and impaired IL-17 production in protein kinase C theta-deficient mice.
    Authors: Tan SL, Zhao J, Bi C, Chen XC, Hepburn DL, Wang J, Sedgwick JD, Chintalacharuvu SR, Na S
    J. Immunol., 2006-03-01;176(5):2872-9.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  26. Modulation of lipopolysaccharide-induced gene transcription and promotion of lung injury by mechanical ventilation.
    Authors: Altemeier WA, Matute-Bello G, Gharib SA, Glenny RW, Martin TR, Liles WC
    J. Immunol., 2005-09-01;175(5):3369-76.
    Species: Mouse
    Sample Types: BALF
  27. Resistance to myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis by death receptor 6-deficient mice.
    Authors: Schmidt CS, Zhao J, Chain J, Hepburn D, Gitter B, Sandusky G, Chintalacharuvu S, Glasebrook A, Na S
    J. Immunol., 2005-08-15;175(4):2286-92.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  28. L-Selectin(hi) but not the L-selectin(lo) CD4+25+ T-regulatory cells are potent inhibitors of GVHD and BM graft rejection.
    Authors: Taylor PA, Panoskaltsis-Mortari A, Swedin JM, Lucas PJ, Gress RE, Levine BL, June CH, Serody JS, Blazar BR
    Blood, 2004-08-03;104(12):3804-12.
    Species: Mouse
    Sample Types: Cell Culture Supernates

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