IL-7R alpha/CD127 Antibody (S08-5I2)

Name: IL-7R alpha/CD127 Antibody (S08-5I2)
Brand: Novus Biologicals
SKU: NBP3-20032
Price: 369 USD
Availability: InStock

Novus Biologicals | Catalog # NBP3-20032

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Product Documents

Recombinant Monoclonal Antibody

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Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S08-5I2 expressed in HEK293

View all IL-7R alpha/CD127 Primary Antibodies »

Product Specifications

Immunogen

A synthetic peptide of human IL-7R alpha/CD127 (Uniprot # P16871)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

70 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Description

Novus Biologicals Rabbit IL-7R alpha/CD127 Antibody (S08-5I2) (NBP3-20032) is a recombinant monoclonal antibody validated for use in WB. All Novus Biologicals antibodies are covered by our 100% guarantee.

Scientific Data Images for IL-7R alpha/CD127 Antibody (S08-5I2)

Western Blot: IL-7R alpha/CD127 Antibody (S08-5I2) [NBP3-20032]

Western Blot: IL-7R alpha/CD127 Antibody (S08-5I2) [NBP3-20032] - Western blot detection of IL-7R alpha/CD127 in K562 cell lysates using NBP3-20032 (1:1000 diluted). Predicted band size: 52kDa. Observed band size: 70kDa.

Applications for IL-7R alpha/CD127 Antibody (S08-5I2)

Application

Recommended Usage

Western Blot

1/1000-1/5000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

0.3 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: IL-7R alpha/CD127

Interleukin-7 is a glycoprotein involved in the regulation of lymphopoiesis. Response of cells to IL7 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is an alpha/gamma chain heterodimer. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. The human and mouse sequence is nearly identical. In humans, severe combined immunodeficiency is caused by genetic defects in IL-7 receptor. The tyrosine residue at the 449 position is a critical signaling site of the intracellular domain of IL-7 receptor. This site is rapidly phosphorylated by janus kinases after the IL-7 receptor is engaged.

Long Name

Interleukin 7 Receptor alpha

Alternate Names

CD127, IL-7 R alpha, IL-7Ra, IL7R, IL7R alpha

Gene Symbol

IL7R

Additional IL-7R alpha/CD127 Products

Product Documents for IL-7R alpha/CD127 Antibody (S08-5I2)

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Product Specific Notices for IL-7R alpha/CD127 Antibody (S08-5I2)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.