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Indiplon

Catalog #: 3597
2 Citations Datasheet / COA / SDS

Discontinued Product

3597 has been discontinued.
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Indiplon | CAS No. 325715-02-4 | GABA-A Receptor Modulators
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Description: Positive allosteric modulator of GABAA; acts at benzodiazepine site
Alternative Names: NBI 34060

Chemical Name: N-Methyl-N-[3-[3-[2-thienylcarbonyl]pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]acetamide

Purity: ≥99%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Potent GABAA receptor positive allosteric modulator that acts at the benzodiazepine site (Ki values are 1.2 and 1.7 nM in rat frontal cortex and cerebellum respectively). Displays ~ 10-fold selectivity for α1 subunit-containing receptors (EC50 values are 2.6, 24, 60 and 77 nM for α1β2γ2, α2β2γ2, α3β3γ2 and α5β2γ2 receptors respectively). Exhibits sedative, hypnotic, anxiolytic and anticonvulsant activity in vivo and is orally active.

Technical Data

M.Wt:
376.43
Formula:
C20H16N4O2S
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
325715-02-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Indiplon

The citations listed below are publications that use Tocris products. Selected citations for Indiplon include:

2 Citations: Showing 1 - 2

  1. Probing the molecular basis for affinity/potency- and efficacy-based subtype-selectivity exhibited by benzodiazepine-site modulators at GABAA receptors.
    Authors: Soderhielm Et al.
    Biochem Pharmacol  2018;158:339
  2. CB1 cannabinoid receptor stimulation during adolescence impairs the maturation of GABA function in the adult rat prefrontal cortex.
    Authors: Cass Et al.
    Mol Psychiatry  2014;19:536

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