receptor positive allosteric modulator that acts at the benzodiazepine site (Ki
values are 1.2 and 1.7 nM in rat frontal cortex and cerebellum respectively). Displays ~ 10-fold selectivity for α
1 subunit-containing receptors (EC50
values are 2.6, 24, 60 and 77 nM for α
2 and α
2 receptors respectively). Exhibits sedative, hypnotic, anxiolytic and anticonvulsant activity in vivo
and is orally active.
Soluble to 50 mM in DMSO
Store at +4°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Characterization of the interaction of indiplon, a novel pyrazolopyrimidine sedative-hypnotic, with the GABAA receptor.
Sullivan et al.
In vivo pharmacological characterization of indiplon, a novel pyrazolopyrimidine sedative-hypnotic.
Foster et al.
Indiplon is a high-affinity positive allosteric modulator with selectivity for α1 subunit-containing GABAA receptors.
Petroski et al.