Catalog Number: 3597
Alternate Names: NBI 34060
Chemical Name: N-Methyl-N-[3-[3-[2-thienylcarbonyl]pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]acetamide
Biological Activity
Potent GABAA receptor positive allosteric modulator that acts at the benzodiazepine site (Ki values are 1.2 and 1.7 nM in rat frontal cortex and cerebellum respectively). Displays ~ 10-fold selectivity for α1 subunit-containing receptors (EC50 values are 2.6, 24, 60 and 77 nM for α1β2γ2, α2β2γ2, α3β3γ2 and α5β2γ2 receptors respectively). Exhibits sedative, hypnotic, anxiolytic and anticonvulsant activity in vivo and is orally active.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Characterization of the interaction of indiplon, a novel pyrazolopyrimidine sedative-hypnotic, with the GABAA receptor.
    Sullivan et al.
    J.Pharmacol.Exp.Ther., 2004;311:537
  2. In vivo pharmacological characterization of indiplon, a novel pyrazolopyrimidine sedative-hypnotic.
    Foster et al.
    J.Pharmacol.Exp.Ther., 2004;311:547
  3. Indiplon is a high-affinity positive allosteric modulator with selectivity for α1 subunit-containing GABAA receptors.
    Petroski et al.
    J.Pharmacol.Exp.Ther., 2006;317:369
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