Chemical Name: 13-cis-Retinoic acid
Biological ActivityEndogenous agonist for retinoic acid receptors. Promotes neurite outgrowth, cell differentiation and inhibits proliferation in a neuroblastoma cell line. Also increases protein expression levels of MYCN and retinoic acid receptor-β. Anti-inflammatory.
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Diamandis et al.
Cellular metabolism and actions of 13-cis-retinoic acid.
Blaner et al.
Metabolic characteristics of 13-cis-retinoic acid (isotretinoin) and anti-tumour activity of the 13-cis-retinoic acid metabolite 4-oxo-13-cis-retinoic acid in neuroblastoma.
Sonawane et al.
Citation for Isotretinoin
The citations listed below are publications that use Tocris products. Selected citations for Isotretinoin include:
1 Citation: Showing 1 - 1
A High Throughput Phenotypic Screening reveals compounds that counteract premature osteogenic differentiation of HGPS iPS-derived mesenchymal stem cells.
Authors: Cicero Et al.
Sci Rep 2016;6:34798
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