Catalog Number: 5513
Alternate Names: 13-cis-retinoic acid, Accutane
Chemical Name: 13-cis-Retinoic acid
Biological Activity
Endogenous agonist for retinoic acid receptors. Promotes neurite outgrowth, cell differentiation and inhibits proliferation in a neuroblastoma cell line. Also increases protein expression levels of MYCN and retinoic acid receptor-β. Anti-inflammatory.
Technical Data
  • M.Wt:
    300.44
  • Formula:
    C20H28O2
  • Solubility:
    Soluble to 100 mM in DMSO and to 20 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at -20°C
  • CAS No:
    4759-48-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Chemical genetics reveals a complex functional ground state of neural stem cells.
    Diamandis et al.
    Nat.Chem.Biol., 2007;3:268
  2. Cellular metabolism and actions of 13-cis-retinoic acid.
    Blaner et al.
    J.Am.Acad.Dermatol., 2001;45:S129
  3. Metabolic characteristics of 13-cis-retinoic acid (isotretinoin) and anti-tumour activity of the 13-cis-retinoic acid metabolite 4-oxo-13-cis-retinoic acid in neuroblastoma.
    Sonawane et al.
    Br.J.Pharmacol., 2014;171:5330

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